BACKGROUND: Platelet-rich plasma (PRP), derived from peripheral blood, contains bioactive mediators that support cellular repair and tissue regeneration. PRP is thought to play a key role in the repair of ovarian tissue post-ovulation and m…
BACKGROUND: The role of serum progesterone levels and the benefit of rescue luteal support in frozen embryo transfer (FET) cycles remain debated. While low serum progesterone has been linked to poorer outcomes, evidence on whether supplemen…
OBJECTIVE: To investigate the association between serum estradiol (E2) levels on the day of embryo transfer and clinical pregnancy outcomes in hormonally prepared frozen–thawed embryo transfer (HRT-FET) cycles with optimal progesterone (P4)…
Background: Endometriosis, a common cause of infertility, adversely impacts both the quality and quantity of oocytes and embryos, with increasing severity negatively influencing assisted reproductive technology (ART) outcomes. This study ai…
BACKGROUND: Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was d…
OBJECTIVES: NOTCH signaling pathway is well known for its role in cell fate, cell survival, cell differentiation, and apoptosis. Some of the NOTCH signaling genes are critical for endometrial function and implantation in animals and appear …
OBJECTIVE: To determine the localization, expression, and function of Toll-like receptors (TLRs) in fallopian tube epithelial cells. METHODS: The localization of TLRs in fallopian tube epithelial cells was investigated by immunostaining. S…
BACKGROUND: The human female reproductive tract (FRT) is constantly deal with the invading pathogens. Recognition of these pathogens is attributed to the family of Toll like receptors (TLR) as a major part of the innate immune system. We an…
The mucosal immune system in the female reproductive tract (FRT) is well equipped to meet the sexually transmitted pathogens, allogeneic sperm, and the immunologically distinct fetus. Analysis of the FRT indicates that epithelial cells prov…