Lin I

ORCID: 0000-0002-6207-1299 · 2 papers in corpus · active 2021-2025
2025
Transcriptional Circuitry in HGSOC: A Dynamic Three-State Model Informed by a Living Biobank of Purified Tumour Fractions
·doi:10.1101/2025.07.18.665513

High-grade serous ovarian cancer (HGSOC) is a heterogeneous disease, but efforts to define transcriptional subtypes using bulk RNA sequencing have been confounded by the presence of non-malignant cells. As a result, it remains unclear wheth…

2021
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes.
Genome medicine ·doi:10.1186/s13073-021-00952-5

BackgroundEpithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC). Al…