Lin I

ORCID: 0000-0002-6207-1299 · 3 papers in corpus
other 2026
The dual roles of uterine monocytes in regulation of tissue homeostasis throughout reproductive cycles in health and disease
Nature immunology ·doi:10.1038/s41590-026-02651-y

Inflammation occurs during the recurring cycles of tissue degradation, repair and remodeling in the uterus, but the mechanisms by which the immune system contributes to uterine tissue integrity are unclear. We reveal that uterine monocytes …

2025
Transcriptional Circuitry in HGSOC: A Dynamic Three-State Model Informed by a Living Biobank of Purified Tumour Fractions
·doi:10.1101/2025.07.18.665513

High-grade serous ovarian cancer (HGSOC) is a heterogeneous disease, but efforts to define transcriptional subtypes using bulk RNA sequencing have been confounded by the presence of non-malignant cells. As a result, it remains unclear wheth…

meta-analysis 2021
Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes
Genome medicine ·doi:10.1186/s13073-021-00952-5

BACKGROUND: Epithelial ovarian cancer (OC) is a heterogenous disease consisting of five major histologically distinct subtypes: high-grade serous (HGSOC), low-grade serous (LGSOC), endometrioid (ENOC), clear cell (CCOC) and mucinous (MOC). …