Fabio C Tucci

No ORCID on file · 2 papers in corpus · active 2004-2008

Study types

  • other 1
  • review 1

Condition tags

  • endometriosis 2
other 2008
Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor
Journal of medicinal chemistry ·doi:10.1021/jm8006454

The discovery of novel uracil phenylethylamines bearing a butyric acid as potent human gonadotropin-releasing hormone receptor (hGnRH-R) antagonists is described. A major focus of this optimization was to improve the CYP3A4 inhibition liabi…

review 2004
Synthesis of orally active small-molecule gonadotropin-releasing hormone antagonists
Current opinion in drug discovery & development

Recent success in the search for orally active gonadotropin-releasing hormone antagonists for the treatment of sex hormone-related diseases, such as endometriosis, uterine fibroids and prostate cancer, has resulted in the discovery of non-p…