Raul Cavalcante Maranhão

article 2023

Pilot study of treatment of patients with deep infiltrative endometriosis with methotrexate carried in lipid nanoparticles

Archives of gynecology and obstetrics ·doi:10.1007/s00404-023-07246-8

OBJECTIVE: Previously, lipid nanoparticles (LDE) injected in women with endometriosis were shown to concentrate in the lesions. Here, the safety and feasibility of LDE carrying methotrexate (MTX) to treat deep infiltrating endometriosis was…

article 2021

Treatment of Deep Infiltrative Endometriosis with Methotrexate Carried in Lipid Core Nanoparticles (LDE): A Pilot Study

·doi:10.1016/j.jmig.2021.09.436

article 2019

Nanotechnology for the treatment of deep endometriosis: uptake of lipid core nanoparticles by LDL receptors in endometriotic foci

Clinics (Sao Paulo, Brazil) ·doi:10.6061/clinics/2019/e989

OBJECTIVE: Rapidly dividing cells in multiple types of cancer and inflammatory diseases undergo high low density lipoprotein (LDL) uptake for membrane synthesis, and coupling an LDL-like nanoemulsion, containing lipid nanoparticles (LDE) to…

article 2016

mRNA levels of low-density lipoprotein receptors are overexpressed in the foci of deep bowel endometriosis

Human Reproduction ·doi:10.1093/humrep/dew303

STUDY QUESTION: Is mRNA expression of LDL receptors altered in deep bowel endometriotic foci? SUMMARY ANSWER: mRNA expression of LDL receptors is up-regulated in deep bowel endometriotic foci of patients with endometriosis. WHAT IS KNOWN AL…

other 2014

Could statins constitute a novel treatment for endometriosis? Systematic review of the literature

European journal of obstetrics, gynecology, and reproductive biology ·doi:10.1016/j.ejogrb.2014.05.028

Endometriosis, defined as the presence of endometrial glands and/or stroma outside the uterine cavity, is an estrogen-dependent disease that affects about 10% of reproductive age women. Theories to explain the etiology of endometriosis abou…