Vermeulen L

ORCID: 0000-0002-6066-789X · 3 papers in corpus
2025
Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer.
Nature communications ·doi:10.1038/s41467-025-58999-6

Patients with peritoneal metastasized colorectal cancer (PM-CRC) have a dismal prognosis. We hypothesized that an immunosuppressive environment in the peritoneal cavity underlies poor prognosis. We define the composition of the human perito…

2024
T-cell responses in colorectal peritoneal metastases are recapitulated in a humanized immune system mouse model.
Frontiers in immunology ·doi:10.3389/fimmu.2024.1415457

BackgroundThe occurrence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) has a dismal prognosis. There is often limited response to systemic- and immunotherapy, even in microsatellite unstable (MSI) CRC. To overcome t…

2015
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.
Carcinogenesis ·doi:10.1093/carcin/bgv039

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of ca…