Huang Z

PURPOSE: This study aimed to evaluate the pregnancy outcomes of frozen embryo transfer (FET) in patients with persistent chronic endometritis (PCE). METHODS: 186 patients were stratified into three groups: Cured CE (CCE), Cured Persistent …

OBJECTIVES: Accessory cavitated uterine malformation (ACUM) is a congenital Müllerian duct developmental anomaly. Clinically, it is commonly observed in young women presenting with progressive lower abdominal pain. Due to the small size of …

BACKGROUND: Germline mutations in genes governing DNA repair, cell cycle regulation, and epigenetic modification are now recognized as common etiological factors for both cancer predisposition and reproductive dysfunction. This reveals a pr…

Endometriosis (EM) affects approximately 10% of women of reproductive age and remains a prevalent estrogen-dependent gynecological disorder with limited therapeutic efficacy and high recurrence rates. Ferroptosis-an iron-dependent, non-apop…

Endometriosis (EMs) is characterized by the establishment and persistence of ectopic lesions, a process fundamentally dependent on aberrant angiogenesis. Endothelial cells (ECs) play a central role in this process; however, accumulating evi…

OBJECTIVE: The Progestin-Primed Ovarian Stimulation (PPOS) protocol with a freeze-all strategy is increasingly used for diminished ovarian reserve (DOR) patients. While growth hormone (GH) and Kuntai capsule are proposed adjuvants, their ef…

BACKGROUND: Migraine is a very common chronic neurological disorder associated with severe disability and significant social burden worldwide. Beyond recurrent headache attacks, increasing evidence indicates that migraine often coexists wit…

PURPOSE: Pain-related fear (PRF) is increasingly recognized as a clinically relevant psychological factor in chronic pain, yet its role in attentional processing across varying threat levels remains unclear, particularly in functional visce…

Endometriosis is a prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, often causing chronic pain, infertility, and systemic inflammation. Accurate detection and complete surgical resection remain ch…

This study aimed to delineate the molecular profile underlying progesterone resistance in atypical endometrial hyperplasia (AEH), a precancerous condition associated with a high risk of malignant transformation. Using a retrospective cohort…

Endometriosis (EMs) is a disease characterized by the presence of endometrial tissue outside the uterus, which often causes pain, abnormal bleeding, and infertility. Sirtuin 1 (SIRT1)-mediated deacetylation is implicated in the progression …

The female immune system operates within an evolutionary stability-plasticity trade-off, where the physiological demands of pregnancy necessitate a considerable degree of regulatory T cell (Treg) plasticity. This essential flexibility, howe…

OBJECTIVE: To systematically evaluate the effects of acupuncture and moxibustion on pain relief, inflammatory biomarkers, and reproductive outcomes in patients with chronic pelvic inflammatory disease (CPID). METHOD: A systematic search wa…

BACKGROUND: Infertility poses a significant health challenge for reproductive-aged women globally and could be shaped by both genetic risks and lifestyle factors. Existing studies predominantly focus on individual lifestyle components, whil…

Accumulated evidence has shown that the antioxidant diet exhibits protective effects on women's reproductive health. The Composite Dietary Antioxidant Index (CDAI) serves as a crucial indicator for assessing antioxidant-rich diets. However,…

BACKGROUND: Endometriosis is a chronic inflammatory disease with a prevalence of approximately 10% in women of childbearing age. Metabolic pathways have been demonstrated by previous studies to be potential avenues for the development of ne…

The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been extensively documented since its discovery in 2013. The cGAS-STING signaling pathway is activated u…

OBJECTIVE: To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) tail anchoring to the superficial myometrium under hysteroscopic direct vision. METHODS: From March 1, 2017, to March 1, 2022, 206 pa…

OBJECTIVE: To investigate the determinants affecting live birth outcomes in fresh embryo transfer among polycystic ovary syndrome (PCOS) patients using various machine learning (ML) algorithms and to construct predictive models, offering no…

PURPOSE: To evaluate the relationships between the sperm DNA fragmentation index (DFI) and semen parameters and its application in fresh embryos via in vitro fertilization and transfer. METHODS: A retrospective propensity score matching (P…

Neutrophils are key immune components in rheumatoid arthritis (RA), but the role of ALKBH5 in neutrophil function and RA progression remains unclear. METTL3, METTL14, WTAP, ALKBH5, FTO, YTHDF2, autophagy related gene were investigated by RT…

Chronic widespread pain (CWP) remains challenging due to its heterogeneous causes and complex mechanisms. A total of 2920 plasma proteins are analyzed from 29,254 UK Biobank participants. A total of 256 proteins are identified as cross-sect…

PURPOSE: Maternal age-related fertility decline is considered to be directly attributed to either embryonic or endometrial factors. Aneuploidy, as the dominant defect in aging embryos, has long diverted attention away from the effects of en…

Whether and how endometrial aging affects fertility remains unclear. In our in-house clinical cohort at the Center for Reproductive Medicine of Peking University Third Hospital (n = 1,149), we observed adverse pregnancy outcomes in the midd…

Leiomyomas (LM) and adenomyosis (AM) are common gynecological diseases with high incidence rates and an increasing trend of affecting younger women. Accurate detection and differentiation of LM and AM in ultrasound images are crucial for se…