Masahide Hamaguchi

review 2026

Functional Impairment of Activated Regulatory T Cells as a Central Immunological Defect in Endometriosis

Reproductive medicine and biology ·doi:10.1002/rmb2.70051

BACKGROUND: Endometriosis is increasingly recognized as a disorder of impaired reproductive immune tolerance rather than solely an endocrine disease. Although previous studies have reported inconsistent findings regarding the number of regu…

other 2025

Adoptive transfer of regulatory T cells inhibits the progression of endometriosis-like lesions in regulatory T-cell-depleted mice

Human Reproduction ·doi:10.1093/humrep/deaf054

STUDY QUESTION: Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis? SUMMARY ANSWER: Adoptive transfer of Tregs suppresses the progression of endometriosis and reduces the levels of helper T (Th)-ce…

article 2023

Decrease in activated regulatory T cell populations in the endometrium during ovulation in endometriosis

Journal of Reproductive Immunology ·doi:10.1016/j.jri.2023.103825

Endometriosis is a serious disorder that can lead to infertility. The immune system, particularly regulatory T cells (Tregs), is involved in endometriosis and infertility; however, endometriosis-associated infertility is poorly understood. …

article 2021

Reduced innate lymphoid cells in the endometrium of women with endometriosis

American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.13502

PROBLEM: Innate lymphoid cells (ILCs), a recently discovered family of innate immune cells, are responsible for the early immune response, and control both innate and adapted immune system via cytokine secretion. The role of ILCs in endomet…