René Pool

No ORCID on file · 4 papers in corpus
2025
Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts
·doi:10.1101/2025.05.28.25328482

Introduction Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early you…

other 2025
Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility
Journal of assisted reproduction and genetics ·doi:10.1007/s10815-025-03515-4

PURPOSE: Natural dizygotic twinning (DZT) results from hyper-ovulation and is an indicator of female fertility. However, some traits linked to DZ twinning are also associated with infertility. We examined the relationship between DZT and fe…

2024
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.
Human reproduction (Oxford, England) ·doi:10.1093/humrep/dead247

Study questionWhich genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins?Summary answerWe identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and…

other 2024
Polygenic Scores for Dizygotic Twinning: Insights into the Genetic Architecture of Female Fertility
medRxiv : the preprint server for health sciences ·doi:10.1101/2024.12.02.24318308

Natural dizygotic twinning (DZT) results from hyper-ovulation and is considered an indicator of female fertility. DZT has low polygenicity, with only 0.20% of SNPs estimated to have a nonzero effect. A polygenic score (PGS) for DZT explains…