Zhang W

CXC chemokine ligand 8 (CXCL8) has emerged as a critical mediator in tumorigenesis. This study aims to elucidate the role of CXCL8 in the initiation and progression of papillary thyroid carcinoma (PTC). Comprehensive bioinformatic analyses …

This study attempted to evaluate the incidence of incidentalomas based on computed tomography (CT) in colorectal cancer (CRC) patients. CRC patients who obtained plan or enhanced CT for the whole abdominal and pelvis were included at the Fi…

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the in…

BACKGROUND: Endometriosis (EMs) is a persistent inflammatory condition whose three main symptoms, mass, pain, and infertility, severely affect female patients of childbearing age. Hu-Po-San (HPS), a preparation consisting of various herbal …

Abnormal post-translational modifications (PTMs) play a crucial role in tumor initiation and progression. However, the mechanisms by which lncRNAs, as emerging epigenetic regulators, mediate PTMs remain largely unexplored. This review provi…

Premature ovarian insufficiency (POI) is one of the most common diseases contributing to declining fertility globally. Autoimmune dysregulation has been implicated in POI, but the role of B cell and its subsets in immune dysregulation in PO…

OBJECTIVE: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). O…

Endometriosis (EM) is a chronic inflammatory disease that is one of the most common causes of gynecological systemic lesions in women before menopause. The most representative histological feature of EM is that the endometrium appears outsi…

Organoids are three-dimensional tissue analogues grown in vitro. Although they are not human organs in the strict sense, they can mimic the structure and function of tissues in vivo to the maximum extent, and have broad application prospect…

Polycystic ovary syndrome (PCOS), a common female endocrine disorder marked by disrupted folliculogenesis and hyperandrogenism, is increasingly linked to oxidative stress. Despite this association, the mechanistic basis remains poorly chara…

Dual-omics, by integrating molecular information from two distinct dimensions, can offer more comprehensive perspective for complex disease. Herein, we developed an efficient functionalized mesoporous nanoparticle-coupled laser desorption/i…

ObjectiveTo explore the relationship between the level of endogenous sex hormones in the luteal phase and the pain threshold of healthy subjects, and to find the influencing factors of the change in female pain threshold.MethodsSixty-eight …

Background and aimsEnvironmental pollutants, particularly organochlorine insecticides like endosulfan (ENDO), are increasingly linked to liver toxicity and related diseases. Despite its widespread historical use, the mechanisms underlying E…

Evidence suggest that dietary advanced glycation end products (AGEs) might exert harmful effects on female reproductive function. However, population-based studies exploring the associations between dietary AGEs intake and female infertilit…

ObjectiveTo explore the correlation between antinuclear antibodies (ANAs) and pregnancy loss (PL), and to observe its impact on the pregnancy outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) …

BACKGROUND: Despite proposed mechanisms hypotheses, the etiology of adenomyosis remains unclear. The limited efficacy of current therapeutic approaches may stem from insufficient understanding of its pathobiological underpinnings and the pr…

BackgroundTuberculosis can negatively impact both overall health and female reproductive function. This study investigated the relationship between the interferon-gamma release assay (IGRA) status and pregnancy outcomes in infertile women, …

BackgroundIdiopathic pulmonary fibrosis (IPF), a relentlessly progressive lung disorder marked by unremitting extracellular matrix deposition, continues to challenge clinical management due to its enigmatic etiology. Emerging evidence posit…

The aim of this study is to investigate the characteristics and etiology of endometrial hyperemia in patients with polycystic ovary syndrome (PCOS) through two complementary approaches: clinical data analysis to characterize endometrial hyp…

BackgroundInfertility poses a significant burden on both global and national scales. However, the epidemiology of primary infertility among reproductive-aged couples in China remains poorly understood. Therefore, this study aimed to investi…

Tumor-associated neutrophils (TANs) contribute to breast cancer (BC) progression, and aquaporin 9 (AQP9) plays a critical role in tumor development. However, the interactions between TANs and AQP9 in BC are poorly understood. Bioinformatics…

BACKGROUND: Adenomyosis, typically associated with heavy menstrual bleeding and pelvic pain, is rarely linked to neurological complications. This case presents a rare instance of ischemic stroke in a young patient with adenomyosis and vascu…

The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision repair pathway by recognizing and excising the oxidative base lesions including 7,8-dihydro-8-oxoguanine (8-oxoG). Beyon…

BackgroundAccording to statistics, ovarian cancer (OV) is the most prevalent type of gynecologic malignancy and has the highest mortality rate of all gynecologic tumors. Although several studies have shown that oxidative stress (OS) contrib…

This report described three cases with long-term severe dysmenorrhea, and these cases were referred to our department for medical help. The diagnosis of accessory cavitated uterine malformation (ACUM) was considered based on symptoms and ul…