Daly MJ

No ORCID on file · 4 papers in corpus · active 2013-2023
2023
FinnGen provides genetic insights from a well-phenotyped isolated population.
Nature ·doi:10.1038/s41586-022-05473-8

Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding …

2021
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease.
European journal of human genetics : EJHG ·doi:10.1038/s41431-020-00730-8

Multivariate methods are known to increase the statistical power to detect associations in the case of shared genetic basis between phenotypes. They have, however, lacked essential analytic tools to follow-up and understand the biology unde…

2018
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study.
Nature communications ·doi:10.1038/s41467-018-03910-9

Protein-truncating variants can have profound effects on gene function and are critical for clinical genome interpretation and generating therapeutic hypotheses, but their relevance to medical phenotypes has not been systematically assessed…

2013
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.
Nature genetics ·doi:10.1038/ng.2711

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype da…