Tatsuya Watanabe

ORCID: 0000-0001-6841-2587 · 3 papers in corpus
article 2016
Differential micro ribonucleic acid expression profiling in ovarian endometrioma with leuprolide acetate treatment
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.13137

AIM: Micro ribonucleic acids (miRNAs) play an important pathological role in endometriosis. Leuprolide acetate, an analog of gonadotropin-releasing hormone, is widely used to treat endometriosis; however, the molecular mechanisms involved i…

article 2015
Differential mRNA expression profiling in ovarian endometriotic tissue with versus without leuprolide acetate treatment
Journal of Obstetrics and Gynaecology Research ·doi:10.1111/jog.12768

AIM: Leuprolide acetate, an analog of gonadotropin-releasing hormone (GnRH), regresses endometriotic tissue and reduces pain, resulting in clinical improvement upon treatment. The molecular mechanisms involved in the regression of endometri…

other 2014
Suppression of the hypothalamic-pituitary-gonadal axis by TAK-385 (relugolix), a novel, investigational, orally active, small molecule gonadotropin-releasing hormone (GnRH) antagonist: studies in human GnRH receptor knock-in mice
European journal of pharmacology ·doi:10.1016/j.ejphar.2013.12.001

TAK-385 (relugolix) is a novel, non-peptide, orally active gonadotropin-releasing hormone (GnRH) antagonist, which builds on previous work with non-peptide GnRH antagonist TAK-013. TAK-385 possesses higher affinity and more potent antagonis…