BACKGROUND: Ovarian cancer (OC) remains a major global health issue, often diagnosed late and lacking effective screening. METHODS: MR studies until 11 September 2023 were identified by a systematic search across nine databases. We complie…
BACKGROUND: Ovarian cancer (OC) is often diagnosed at an advanced stage when prognosis is poor. We aimed to identify blood plasma proteins predictive of OC risk. METHODS: We conducted proteome-wide Mendelian randomisation (MR) analyses usi…
Data available on lifestyle-associated hormonal and medical factors among endometrial cancer (EC)-affected women who carry the Lynch Syndrome (LS) mutation is limited. The aim of the present retrospective case study was to compare the repro…
BACKGROUND: Lynch syndrome (LS) is associated with a significant lifetime risk of endometrial cancer (EC). There are limited data on factors modifying the EC risk in LS patients. METHODS: The study cohort included 136 LS mutation-positive …