Wang Y

OBJECTIVE: This study investigated the therapeutic effects and mechanisms of IL-17A neutralisation on renal interstitial fibrosis and inflammation in spontaneously hypertensive rats (SHRs). METHODS: SHRs were treated with an IL-17A-neutral…

OBJECTIVE: To describe a mesentery-preserving, nerve-sparing laparoscopic technique for rectal endometriosis. DESIGN: Retrospective cohort study. SETTING: Single centre. POPULATION OR SAMPLE: Women requiring bowel resection for rectal en…

Endometriosis is an estrogen-dependent inflammatory disorder that often persists or returns even after visible lesions have been removed. The behavior of peritoneal macrophages may help explain this clinical durability. These cells particip…

Metabolism-regulating microspheres have evolved from conventional drug carriers into active platforms capable of spatiotemporally reprogramming pathological metabolic networks. Chronic diseases are increasingly understood to be driven by me…

This study evaluates the synergistic therapeutic effect of metformin (MET) combined with medroxyprogesterone acetate (MPA) on endometriosis (EM) and investigates the involvement of the steroid receptor coactivator-1 (SRC-1) and mitogen-indu…

BACKGROUND: Endometriosis is a heterogeneous gynecological disorder characterized by chronic pain, infertility, and substantial impairment of quality of life. Increasing evidence indicates that microRNAs (miRNAs) are key regulators of endom…

Polycystic ovary syndrome (PCOS), one of the most common endocrine and reproductive disorders in women of reproductive age, is frequently complicated by insulin resistance (IR), which affects 50%–80% of PCOS patients and is strongly associa…

Comprehensive magnetic resonance imaging (MRI) analysis in oncology involves multiple interrelated tasks including volumetric segmentation, grading, staging, and malignancy detection. However, most existing deep learning models are task-spe…

ObjectivesThis study aimed to develop a multimodal predictive model that integrates clinical data, radiomics, and three-dimensional deep learning to forecast acute respiratory distress syndrome in patients with acute pancreatitis.MethodsThi…

Diabetic kidney disease (DKD) is a prevalent complication in individuals with diabetes. Efferocytosis plays a pivotal role in chronic diseases; however, the precise mechanisms involved in DKD are still not fully understood. DKD-related data…

BACKGROUND: Endometriosis (EM) is a chronic inflammatory gynaecological disorder affecting approximately 10% of women of reproductive age. Early diagnosis remains challenging because definitive diagnosis still relies on invasive surgical co…

Endometriosis is a chronic inflammatory disease characterised by pain, infertility and recurrence. Current pharmacological management relies largely on hormonal suppression, which can reduce pain and disease activity but does not eradicate …

Obesity is a systemic metabolic disorder that is inducing factor for other diseases such as diabetes mellitus, cardiovascular diseases, malignancies, hepatic dysfunction, renal dysfunction and endometrial diseases. Emerging evidence has sho…

OBJECTIVE: Obesity impairs endometrial receptivity; however, the mechanism remains unclear. Obesity is associated with elevated leptin levels, and leptin receptor (Ob-Rb) has been demonstrated to be expressed in the human endometrium, but t…

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

Organoids are three-dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering h…

The emergence of organoids has received widespread attention for faithful recapitulation of physiological and pathological conditions, together with overcoming the major bottleneck of extrapolating laboratory findings from model systems to …

Objectives: Although blastocyst transfer may improve embryo selection and early pregnancy outcomes, its impact on live birth in women with recurrent implantation failure (RIF) remains uncertain. This study compared reproductive and perinata…

BACKGROUND: This study investigates the clinical characteristics, treatment strategies, and prognosis of ovarian leiomyoma, with the goal of enhancing diagnostic accuracy and therapeutic outcomes for this rare condition. METHODS: We retrosp…

Cardiovascular and cerebrovascular diseases (CVDs) are closely associated with disturbances in vascular homeostasis, including endothelial dysfunction, abnormal vascular remodeling, inflammation, oxidative stress, thrombosis, barrier disrup…

BACKGROUND AND OBJECTIVE: Poly(ADP-ribose) polymerase inhibitors (PARPis) have fundamentally changed the treatment paradigm for patients with ovarian cancer, especially in tumors with homologous recombination deficiency (HRD). However, acqu…

Endometriosis is a debilitating, estrogen-dependent gynecological disorder characterized by profound diagnostic delays due to clinical reliance on invasive laparoscopy. Developing noninvasive, point-of-care biomarker assessment remains a cr…

Background: Polydatin has shown anti-inflammatory, antioxidant, and cytoprotective effects in preclinical studies. Its development is limited by low oral bioavailability, extensive metabolism, and poorly defined tissue exposure. Objectives:…

Endometriosis is a prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, often causing chronic pain, infertility, and systemic inflammation. Accurate detection and complete surgical resection remain ch…

LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in fav…