Melson E

ORCID: 0000-0003-0685-4819 · 2 papers in corpus

2026

Inhibition of the androgen-activating enzyme AKR1C3 selectively decreases systemic and intra-adipose 11-oxygenated androgens in women

·doi:10.64898/2026.03.27.714735

Androgen excess drives metabolic and reproductive complications in polycystic ovary syndrome (PCOS), affecting 10-15% of women globally. Aldo-keto reductase 1C3 (AKR1C3) converts inactive precursors from both the classic and the recently id…

2020

Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome.

Therapeutic advances in endocrinology and metabolism ·doi:10.1177/2042018820934319

Polycystic ovary syndrome (PCOS) has been traditionally perceived as a reproductive disorder due to its most common presentation with menstrual dysfunction and infertility. However, it is now clear that women with PCOS are at increased risk…