Alexander Brown

ORCID: 0000-0003-0291-2081 · 3 papers in corpus
lab-animal 2023
Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk
Med (New York, N.Y.) ·doi:10.1016/j.medj.2023.07.004

BACKGROUND: The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone-mediated signaling may be linked to myriad …

2021
Organoid co-culture model of the cycling human endometrium in a fully-defined synthetic extracellular matrix reveals epithelial-stromal crosstalk
·doi:10.1101/2021.09.30.462577

Summary The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone cycles is linked to myriad gynecological disord…

lab-animal 2017
On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks
Biomaterials ·doi:10.1016/j.biomaterials.2017.03.030

Methods to parse paracrine epithelial-stromal communication networks are a vital need in drug development, as disruption of these networks underlies diseases ranging from cancer to endometriosis. Here, we describe a modular, synthetic, and …