Alexander Brown

ORCID: 0000-0003-0291-2081 · 2 papers in corpus · active 2017-2021

Study types

  • other 1
  • preprint 1

Condition tags

  • endometriosis 1
preprint 2021
Organoid co-culture model of the cycling human endometrium in a fully-defined synthetic extracellular matrix reveals epithelial-stromal crosstalk
·doi:10.1101/2021.09.30.462577

Summary The human endometrium undergoes recurring cycles of growth, differentiation, and breakdown in response to sex hormones. Dysregulation of epithelial-stromal communication during hormone cycles is linked to myriad gynecological disord…

other 2017
On-demand dissolution of modular, synthetic extracellular matrix reveals local epithelial-stromal communication networks
Biomaterials ·doi:10.1016/j.biomaterials.2017.03.030

Methods to parse paracrine epithelial-stromal communication networks are a vital need in drug development, as disruption of these networks underlies diseases ranging from cancer to endometriosis. Here, we describe a modular, synthetic, and …