Pawson AJ

ORCID: 0000-0003-2280-845X · 5 papers in corpus · active 2007-2019

Study types

  • review 1

Condition tags

  • endometriosis 1
  • infertility 1
2019
British journal of pharmacology ·doi:10.1111/bph.14748

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology…

2009
PloS one ·doi:10.1371/journal.pone.0008400

The existence of a hypothalamic gonadotropin-inhibiting system has been elusive. A neuropeptide named gonadotropin-inhibitory hormone (GnIH, SIKPSAYLPLRF-NH(2)) which directly inhibits gonadotropin synthesis and release from the pituitary w…

review 2008
Frontiers in neuroendocrinology ·doi:10.1016/j.yfrne.2007.06.002

Geoffrey Wingfield Harris' demonstration of hypothalamic hormones regulating pituitary function led to their structural identification and therapeutic utilization in a wide spectrum of diseases. Amongst these, Gonadotropin Releasing Hormone…

2008
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2006-0537

GnRH and its receptor are expressed in human reproductive tract cancers, and direct antiproliferative effects of GnRH analogs have been demonstrated in cancer cell lines. The intracellular signaling responsible for this effect differs from …

2007
Molecular endocrinology (Baltimore, Md.) ·doi:10.1210/me.2006-0253

The asynchronous secretion of gonadotrope LH and FSH under the control of GnRH is crucial for ovarian cyclicity but the underlying mechanism is not fully resolved. Because prostaglandins (PG) are autocrine regulators in many tissues, we det…