Zhang Y

Polycystic ovary syndrome (PCOS), one of the most common endocrine and reproductive disorders in women of reproductive age, is frequently complicated by insulin resistance (IR), which affects 50%–80% of PCOS patients and is strongly associa…

BACKGROUND: Infertility remains a global health challenge that often necessitates invasive and costly diagnostic procedures. While the vaginal microenvironment is known to influence reproductive health, its potential as a source of non-inva…

Early identification of malignant ovarian tumors is critical for informing treatment decisions and enhancing patients' quality of life. As the third most prevalent gynecologic cancer globally, ovarian cancer remains challenging to diagnose …

OBJECTIVE: To explore the correlation between autoantibodies, ultrasonic endometrial receptivity parameters and early miscarriage in recurrent spontaneous abortion (RSA) patients during subsequent pregnancies, and to establish and validate …

Obesity is a systemic metabolic disorder that is inducing factor for other diseases such as diabetes mellitus, cardiovascular diseases, malignancies, hepatic dysfunction, renal dysfunction and endometrial diseases. Emerging evidence has sho…

RESEARCH QUESTION: Is there a relationship between the location of adenomyosis lesions and obstetric and neonatal outcomes? DESIGN: A total of 466 women diagnosed with adenomyosis via transvaginal ultrasound between January 2019 and Decemb…

Novel brominated flame retardants (NBFRs), including 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), are emerging endocrine-disrupting chemicals, though their direct effects on female gamete maturation remain insufficiently characterized. In …

The "gut microbiota-mitochondria axis" has become the core hub connecting the metabolism, immunity, and endocrine regulation of gynecological diseases. In this review, the hierarchical regulation mechanism of this axis is systematically com…

Panax ginseng C.A. Meyer, a renowned medicinal herb, exerts many of its systemic effects through intricate interactions with the gut microbiota, a relationship that also addresses the challenge of its own limited oral bioavailability. This …

Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs…

Lymph node metastasis (LNM) is a key factor in the recurrence and progression of papillary thyroid carcinoma (PTC). Phosphodiesterase 4C (PDE4C) serves as a crucial regulator in cancer development and metastasis, its functional role and mec…

OBJECTIVE: To compare perioperative safety, efficiency and learning curves of MPLH, RASPH and SPLH, and analyze surgical disparities stratified by uterine volume. We adopted multivariable regression (primary adjusted analysis) and multinomi…

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

Spinal cord injury (SCI) is a serious neurological system disease. After SCI, a series of cascade reactions can cause irreversible damage, with a high disability rate and mortality rate. The complexity of the pathological mechanism of SCI l…

Polygonatum odoratum (Mill.) Druce (Angular Solomon's seal) is a medicinal and edible plant belonging to the Asparagaceae family. Phytochemical investigations have revealed its diverse chemical constituents. This review systematically summa…

BACKGROUND: Mixed gestational trophoblastic neoplasia (GTN) is an exceptionally rare form of GTN, characterized by the coexistence of choriocarcinoma (CC) and/or placental site trophoblastic tumor (PSTT) and/or epithelioid trophoblastic tum…

Endometrioid carcinoma is one of the most prevalent malignant neoplasms in gynecology, in contrast to perivascular epithelioid cell tumor (PEComa), a rare stromal tumor, which is seldom encountered in the female genital system. The coexiste…

OBJECTIVE: To evaluate the predictive value of deep myometrial invasion (DMI) for lymph node metastasis (LNM) in low-grade endometrioid carcinoma (LGEC) and its implications for surgical decision-making. METHODS: A retrospective cohort stu…

AIM: To systematically assess the prevalence of sexual dysfunction among patients suffering from endometriosis. METHODS: A literature search was carried out using databases such as PubMed, Web of Science, CNKI, and Wanfang from the incepti…

In this study, we identified a number of biological processes, pathways, and key protein targets associated with coenzyme metabolism in bovine clinical mastitis (CM). The expression patterns and subcellular localization of key proteins were…

OBJECTIVE: To develop and compare a random survival forest (RSF) model and a Cox regression model-for predicting postoperative recurrence in patients with ovarian endometrioma. METHODS: The primary outcomes of the study were the recurrence…

BACKGROUND: The relationship between the vascular flow index (VFI) of the endometrium and the pregnancy outcome in the frozen embryo transfer (FET) cycle remains controversial, and there is currently no recommended optimal range for VFI. O…

BACKGROUND: Endometriosis (EMs) is often classified as a benign disease; however, it exhibits malignant biological characteristics. Collapsin Response Mediator Protein 4 (CRMP4) has been implicated in the regulation of cell migration and in…

Age-related fertility decline is an increasingly important challenge in reproductive medicine, driven largely by progressive ovarian aging. The aging ovary undergoes functional deterioration characterized by reduced ovarian reserve and decl…