Amory JK

ORCID: 0000-0002-7419-435X · 1 paper in corpus

2009

Oral administration of the GnRH antagonist acyline, in a GIPET-enhanced tablet form, acutely suppresses serum testosterone in normal men: single-dose pharmacokinetics and pharmacodynamics.

Cancer chemotherapy and pharmacology ·doi:10.1007/s00280-009-1038-1

PurposeGnRH analogs are useful for the treatment of prostate cancer, but require parenteral administration. The peptide GnRH antagonist acyline potently suppresses luteinizing hormone (LH) and testosterone in man; however, its clinical util…