Shynlova O

No ORCID on file · 6 papers in corpus · active 2014-2026
2026
The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1007/s43032-026-02108-5

Around 10% of global births are preterm (before 37 weeks of gestation), posing a significant challenge to maternal and neonatal health. Preterm infants face an increased risk of mortality and long-term health complications, impacting their …

2021
A Broad-Spectrum Chemokine Inhibitor Blocks Inflammation-Induced Myometrial Myocyte-Macrophage Crosstalk and Myometrial Contraction.
Cells ·doi:10.3390/cells11010128

Prophylactic administration of the broad-spectrum chemokine inhibitor (BSCI) FX125L has been shown to suppress uterine contraction, prevent preterm birth (PTB) induced by Group B Streptococcus in nonhuman primates, and inhibit uterine cytok…

2021
Decidual Inflammation Drives Chemokine-Mediated Immune Infiltration Contributing to Term Labor.
Journal of immunology (Baltimore, Md. : 1950) ·doi:10.4049/jimmunol.2100493

Infiltration of maternal peripheral leukocytes into the uterine tissues is a critical event occurring before, during, and after term labor (TL). In this article, we investigate the contribution of uterine smooth muscle (myometrium) and preg…

2021
Landscape of Preterm Birth Therapeutics and a Path Forward.
Journal of clinical medicine ·doi:10.3390/jcm10132912

Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50 years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic agents are drugs that briefly delay PTB, typically to all…

2014
Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse.
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719113512529

AimThe molecular etiology of pelvic organ prolapse (POP) is complex and not well understood. We compared the expression/activity of extracellular matrix (ECM)-processing (procollagen I N-proteinase/ a disintegrin and metalloproteinase with …

2014
Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice.
Journal of cellular and molecular medicine ·doi:10.1111/jcmm.12307

Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. Maternal infection can result in PTB. We investigated the ability of a Broad Spectrum Chemokine Inhibitor (BSCI) to prevent infection-induce…