Hengwei Liu

ORCID: 0000-0002-5753-8704 · 30 papers in corpus
lab-animal 2016
17 β-Estradiol promotes vascular endothelial growth factor expression via the Wnt/β-catenin pathway during the pathogenesis of endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaw025

STUDY HYPOTHESIS: Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis and how? STUDY FINDING: 17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF in effector…

lab-animal 2016
Hypoxia-inducible factor 1α-induced epithelial-mesenchymal transition of endometrial epithelial cells may contribute to the development of endometriosis
Human Reproduction ·doi:10.1093/humrep/dew081

STUDY QUESTION: How does hypoxia promote growth of lesions in the development of endometriosis? SUMMARY ANSWER: Hypoxia induces the epithelial-mesenchymal transition (EMT) of endometrial cells, resulting in changes in cellular characterist…

lab-animal 2016
Intracellular Wnt/Beta-Catenin Signaling Underlying 17beta-Estradiol-Induced Matrix Metalloproteinase 9 Expression in Human Endometriosis
Biology of reproduction ·doi:10.1095/biolreprod.115.135574

Extracellular matrix remodeling is necessary for ectopic endometrium implantation. Many studies have shown an increased expression of matrix metalloproteinase 9 (MMP9) in the ectopic endometrium of endometriosis. However, the signaling path…

lab-animal 2015
Estradiol promotes cells invasion by activating β-catenin signaling pathway in endometriosis
Reproduction (Cambridge, England) ·doi:10.1530/rep-15-0371

Endometriosis is an estrogen-dependent disease that involves the adhesion, invasion, and angiogenesis of endometrial tissues outside of the uterine cavity. We hypothesized that a link exists between estrogen and beta-catenin (β-catenin) sig…

lab-animal 2015
Hypoxia Promotes Invasion of Endometrial Stromal Cells via Hypoxia-Inducible Factor 1α Upregulation-Mediated β-Catenin Activation in Endometriosis
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115607999

Endometriosis is a common benign gynecological disease defined as the presence of endometrial tissue outside the uterine cavity. The aim of this study was to identify the molecular mechanism underlying hypoxia-induced increases in invasive …