Ko L

ORCID: 0000-0002-0089-9090 · 2 papers in corpus

2013

Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations.

The Journal of biological chemistry ·doi:10.1074/jbc.m113.485581

Ovarian cancer is a highly lethal gynecological cancer, and its causes remain to be understood. Using a recently identified tumor suppressor gene, GT198 (PSMC3IP), as a unique marker, we searched for the identity of GT198 mutant cells in ov…

2013

Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers.

Genes & cancer ·doi:10.1177/1947601913486344

The human GT198 gene (gene symbol PSMC3IP) is located at chromosome 17q21, 470 kb proximal to BRCA1, a locus previously linked to breast and ovarian cancer predisposition. Its protein product (also known as TBPIP and Hop2) has been shown to…