Li J

BACKGROUND: LY01021 is a novel oral small-molecule gonadotropin-releasing hormone (GnRH) receptor antagonist intended for the treatment of various sex hormone-dependent disorders. This study aimed to evaluate the safety, tolerability, pharm…

PURPOSE: Infants born after assisted reproductive technology (ART) have more adverse health outcomes than spontaneously conceived infants. Evidence on the impact of ART on the offspring's visual system, particularly refractive errors (REs),…

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

BACKGROUND: Environmental exposure to trace and heavy metals may influence female fertility, yet their impact on assisted reproductive outcomes remains poorly defined. Maternal diet can potentially modulate metal-related toxicity by influen…

BACKGROUND: The impact of the interval between consecutive testicular sperm aspiration (TESA) procedures on pregnancy outcomes of intracytoplasmic sperm injection (ICSI) in patients with obstructive azoospermia (OA) remains controversial. T…

Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality, affecting 3 to 8% of pregnancies. Currently, no clinically useful predictive biomarker exists. Preeclampsia is characterised by systemic inflammatory response…

BACKGROUND: Endometriosis is characterized by inflammation and fibrosis, in which cytokines and cytokine-macrophage interactions serve as critical mediators. However, the specific mechanisms that initiate the fibrotic cascade in endometrios…

BACKGROUND: Chronic hepatitis B (HBV) and hepatitis C (HCV) infections represent a substantial global health burden and increasing numbers of infertile women with chronic HBV/HCV infections seek conception through in vitro fertilization (IV…

The study explored the mechanism of Dan'e-fukang soft extract in treating endometriosis (EMs) through network pharmacology. The main active ingredients of Dan'e-fukang soft extract were analyzed based on the traditional Chinese medicine sys…

OBJECTIVES: To evaluate the efficacy of Honghua Ruyi Pills combined with estradiol valerate and dydrogesterone tablets in promoting endometrial repair and menstrual recovery after artificial abortion. METHODS: This was a randomized, double…

BACKGROUND: Vaginal microbiota dysbiosis has been associated with female reproductive health and infertility. This study aimed to compare vaginal microbiota profiles according to fertility and ovarian induction status among Thai women. MET…

INTRODUCTION: Endometriomsis (EMs) is a complex and chronic gynecological disease characterized by distressing symptoms. Its pathogenesis remains unknown, and there is no effective treatment. Therefore, establishing patient-derived models i…

OBJECTIVE: To investigate the effect of Tiao-Jing-Cu-Yun Acupuncture on pregnancy outcomes in infertility patients with thin endometrium undergoing artificial cycle frozen-thawed embryo transfer (AC-FET). METHODS: A prospective, assessor-b…

OBJECTIVE: The ovary, as an important reproductive organ, tightly regulates the litter size of rabbits through its complex network of genes. This study aims to identify candidate genes related to litter size in rabbits through RNA sequencin…

Abstract Background: Adenomyosis is an estrogen-dependent benign gynecological disorder, although its exact pathophysiology is still mostly unclear. SRY-box transcription factor 9 (SOX9) is an essential transcription factor regulating e…

PURPOSE: Adenomyosis and endometriosis are both recognized as etiological factors in the development of dysmenorrhea; however, their respective contributions to this condition remains ambiguous. This study aims to examine the distinct contr…

Jiaye Li,1 Yang Gao,2 Meiling Sun,3 Chun Chen,1 Jiahui Che,4 Ting Zhao1 1Department of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Reproduction and Development, Shanghai Key Laboratory of Fem…

STUDY OBJECTIVE: To evaluate the effects of a 3-stage treatment strategy featured by cold-knife adenomyomectomy, enhanced endometrial protection and postoperative uterine monitoring for severe diffuse adenomyosis on IVF/ICSI and perinatal o…

YAP1 (Yes-associated protein 1), a central downstream effector of the Hippo signaling pathway, is tightly regulated through coordinated post-transcriptional and post-translational mechanisms. At the post-transcriptional level, expression st…

Currently, hormonal therapy for endometriosis faces challenges in achieving a balance between treatment and preserving the chance of pregnancy. Therefore, the development of non-hormonal therapy holds significant clinical importance. Angiog…

Endometriosis is an estrogen-dependent disease that severely affects the physical and mental health of women of childbearing age. Due to the significant side effects of traditional hormone therapies, non-hormonal treatment strategies are ur…

Multifunctional small-molecule theranostic agents hold significant clinical potential for non-invasive endometriosis (EMS) management. Current EMS treatment faces challenges due to imprecise lesion localization and therapy-associated side e…

Ferroptosis is a potential target for the treatment of endometriosis (EMs). The role of andrographolide (AP) in the ferroptosis has gradually attracted attention, but its mechanism of action in endometriosis has not been clarified. Here we …

High-throughput sequencing enables efficient processing of DNA and RNA samples in batches, but batch effects can obscure true biological signal. We propose using anticlustering as an automated method to assign samples to balanced batches, m…

High throughput sequencing is a powerful tool for processing large amounts of DNA and RNA samples in batches. Proper experimental design and statistical methods are required to mitigate systematic technical factors due to differences in bat…