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BackgroundCervical clear cell adenocarcinoma (CCAC) and cervical endometrioid adenocarcinoma (CEAC) are rare and aggressive non-HPV-associated malignancies. Despite their histological similarities, these subtypes demonstrate distinct biolog…

Persistent organic pollutants (POPs) are a class of chemical substances with environmental persistence, bioaccumulation, and high toxicity, which are widely present in the environment and food chains. Prostate cancer (PCa) is a highly preva…

ObjectiveTo evaluate the predictive value of deep myometrial invasion (DMI) for lymph node metastasis (LNM) in low-grade endometrioid carcinoma (LGEC) and its implications for surgical decision-making.MethodsA retrospective cohort study was…

Perfluorooctanoic acid (PFOA) has been implicated in female reproductive toxicity, while its long-term effects of prenatal exposure remain unclear. Herein, we conducted a comprehensive NHANES analysis to estimate the Hazard Ratio (HR) of ea…

The B‑cell translocation gene 2 (BTG2), originally identified as a tumor suppressor, has been extensively studied in oncology research. However, its multifaceted functions in non‑tumor diseases are still being recognized but not entirely un…

Infected wounds heal considerably slowly among patients with diabetes because of biofilm barriers and immune dysregulation. Therefore, treatment strategies must simultaneously eliminate infection and accelerate healing. In this study, we pr…

Age-related decreases in follicle numbers and oocyte quality are major contributors to the decline in female fertility, which is associated with increased infertility rates. Emerging evidence suggests that targeting granulosa cell senescenc…

BackgroundThe clinical impact of sperm chromatin condensation defects (SCCD) on in vitro fertilization (IVF) outcomes remains controversial. This study aimed to clarify the effects of SCCD on embryonic development, pregnancy, and neonatal o…

Females with iron overload suffer from follicular dysplasia, and effective therapeutic strategies for preserving fertility remain lacking. As a natural aliphatic polyamine, spermidine exerts antioxidant activity and plays an anti-ferroptosi…

Ovarian cancer (OC) is a leading cause of gynecologic cancer mortality, with survival prediction limited by existing prognostic models that fail to capture tumor heterogeneity. Conventional methods lack precision for individualized risk ass…

BACKGROUND: Migraine is a chronic neurological disorder characterized by severe headache, nausea, and sensitivity to light and sound, affecting approximately 1 billion people globally. Despite advances in understanding migraine pathophysiol…

N 6-methyladenosine (m6A) and N6, 2'-O-dimethyladenosine (m6Am) are two RNA modifications that play essential roles in diverse RNA metabolic processes and functions. Despite their importance, the dynamic landscapes and regulatory patterns o…

Red meat consumption is widespread globally and has been associated with endometriosis (EMS) progression, although the precise underlying mechanisms remain unclear. In the present study, we aimed to explore the mechanisms by which a red mea…

The female immune system operates within an evolutionary stability-plasticity trade-off, where the physiological demands of pregnancy necessitate a considerable degree of regulatory T cell (Treg) plasticity. This essential flexibility, howe…

IntroductionAlpha-linolenic acid (ALA), an essential polyunsaturated fatty acid, modulates gastrointestinal microbiota and host immunity, yet its regulatory mechanisms in dairy cows remain unclear.MethodsThis study investigated how dietary …

BackgroundPolycystic ovary syndrome (PCOS) is widely acknowledged as the prevailing reproductive endocrine disorder accompanied by numerous metabolic dysfunctions. However, there has been a lack of systematic examination regarding the amino…

BackgroundThere is limited research about the pregnancy outcomes of POSEIDON group 2 patients. This study aims to evaluate the factors related to the clinical outcomes of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection …

OBJECTIVE: The aim of the present retrospective cohort study was to compare the clinical characteristics, perioperative outcomes and pregnancy outcomes of laparo-endoscopic single-site (LESS) surgery, conventional laparoscopy (CL) surgery a…

BackgroundThis study aims to investigate the efficacy and safety of dexmedetomidine in treating postoperative acute pain through a clinical randomized controlled trial.MethodsThis study selected 165 patients who underwent general anesthesia…

BACKGROUND: Endometriosis is an estrogen-dependent inflammatory disease that is the leading cause of dysmenorrhea, infertility, and pelvic pain in women. A growing body of evidence has demonstrated that platelets may play an important role …

BackgroundMüllerian adenosarcoma (MA) is a rare low-grade malignant tumor. It is characterized by benign glandular epithelium and malignant sarcomatous stromal components. This tumor commonly arises in the uterine corpus. Primary ovarian MA…

ObjectiveThe aim of this study was to comparatively analyze the therapeutic effects of uterine artery embolization (UAE) and laparoscopic myomectomy (LM) on uterine fibroids to determine which treatment method is more beneficial for patient…

The Levonorgestrel-releasing Intrauterine System (LNG-IUS) is extensively utilized in the treatment of adenomyosis. However, the displacement and expulsion of the LNG-IUS bring significant challenges. This was a retrospective analysis compa…

BackgroundPremenstrual dysphoric disorder (PMDD) has been identified as a member of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5). The symptoms of premenstrual syndrome are uncertain, and these uncertain sym…