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BACKGROUND: Choriocarcinoma coexisting with intrauterine pregnancy is extremely rare and necessitates early diagnosis. CASE PRESENTATION: A primigravida at 27+ weeks of gestation presented with a 3-day history of worsening abdominal pain. …

OBJECTIVE: To evaluate whether concomitant laparoscopy during hysteroscopic uterine septum resection is associated with perioperative characteristics and postoperative reproductive outcomes, and to explore the prognostic roles of ESHRE/ESGE…

BACKGROUND: Fumarate hydratase (FH)-deficient uterine leiomyoma is a rare pathologic marker for hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. Its recognition is crucial for initiating life-saving surveillance. CASE P…

Precise regulation of alternative splicing (AS) of maternal mRNAs is crucial for maintaining mRNA homeostasis and for acquiring oocyte competence. However, the regulatory factors and mechanisms of AS regulating oocyte competence and human f…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

BACKGROUND: Endometrial intrauterine adhesions (IUA) arise due to comprised regenerative capacity of endometrium and aberrant fibrotic processes. These adhesions significantly affect fertility by impeding embryo implantation, sustaining pre…

Infertility constitutes a major global health concern, affecting approximately 17.5% of couples of reproductive age. Although advances in assisted reproductive technologies (ART) have expanded treatment options, success rates remain highly …

Premature ovarian failure (POF) and insufficiency induced by cisplatin are common complications associated with gynecological diseases. This study aims to investigate the role of N6-methyladenosine (m6A) methyltransferase METTL16 in cisplat…

Hysterectomy is a frequent gynecological surgical technique. With the extensive application of robot-assisted laparoscopic surgery, the feasibility of robot-assisted transvaginal natural orifice translumenal endoscopic surgery (v-NOTES) has…

BACKGROUND: To assess and compare the efficiency and outcomes between prone split-leg position and lithotomy position in posterior uterine myomectomy by transvaginal natural orifice transluminal endoscopic surgery (vNOTES). METHODS: 33 pat…

BACKGROUND: Pelvic floor surface electromyography (sEMG) is widely used to evaluate and treat pelvic floor dysfunctions (PFDs). Based on sEMG, the Glazer protocol was developed over 20 years ago with a limited sample size, making it challen…

OBJECTIVE: To identify the determinants influencing clinical pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. METHODS: A retrospective analysis was conducted on patients who underwent FET at the Department of Reproductive …

To identify the factors affecting adverse reproductive outcomes in TPOAb-positive patients and to establish a predictive model based on these factors to assess the risk of adverse reproductive outcomes in patients. A retrospective cohort st…

BACKGROUND: The levonorgestrel intrauterine system (LNG-IUS) may have its contraceptive or therapeutic efficacy compromised if displacement or expulsion occurs. By suturing and securing the device to the uterine wall, the risk of expulsion …

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at…

OBJECTIVES: Per- and polyfluoroalkyl substances (PFAS) have been associated with polycystic ovarian syndrome (PCOS), however, the evidence is limited. This study aimed to explore the associations between PFAS in the follicular fluid and PCO…

Songwei Feng,1,* Yuru Wang,1,* Sicong Liu,2,* Yueming Zhang,1 Leilei He1 1Department of Obstetrics and Gynaecology, The Fourth Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Obstetrics and Gyna…

OBJECTIVES: Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes. DESIGN: A retrospective cohort study. SETTING: Wenzhou, Zhengjiang Province, Ch…

The incidence of malignant tumors continues to grow. Still, with the rapid development of various diagnostic and therapeutic techniques, the survival rate of malignant tumors has been improved, and the increased survival rate has introduced…

OBJECTIVE: To compare the outcomes of hysterectomy performed via traditional inpatient procedure versus day-care procedure with a focus on surgical time, post-operative recovery, costs, and patient satisfaction, using propensity score match…

BACKGROUND: Acupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects r…

The production of high-quality oocytes requires precisely orchestrated intercellular communication. Extracellular vesicles (EVs) are cell-derived nanoparticles that play a vital role in the transfer of bioactive molecules, which has gained …

BACKGROUND: Gasless transvaginal natural orifice transluminal endoscopic surgery (G-vNOTES) can avoid complications related to pneumoperitoneum, but there is limited research on G-vNOTES. Here, we aimed to compare the hemodynamic profiles a…

BACKGROUND: This retrospective study aimed to examine the influence of hormonal and metabolic parameters across varying body mass index (BMI) levels on embryo quality and pregnancy outcomes in fresh embryo transfer cycles using assisted rep…