Smith P

STUDY QUESTION: Does anti-Müllerian hormone (AMH) influence preantral follicle development within a short range of AMH-secreting antral follicles? SUMMARY ANSWER: Immunization of sheep against AMH leads to increased follicle survival, spec…

OBJECTIVE: To compare recovery after laparoscopic hysterectomy (LH) and abdominal hysterectomy (AH). DESIGN: A parallel, open, non-inferiority, multicentre, randomised controlled, expertise-based surgery trial. SETTING: 10 NHS (National H…

BACKGROUND: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a complex, chronic condition affecting the urinary bladder. Symptoms commonly associated with IC/BPS include painful urination, pain during intercourse, a persistent or rec…

The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably o…

BACKGROUND: The development of chemoresistance to paclitaxel and carboplatin represents a major therapeutic challenge in ovarian cancer, a disease frequently characterized by malignant ascites and extrapelvic metastasis. Microtentacles (McT…

Ovarian cancer has received national attention as a highly virulent disease. Its lack of early warning symptoms and the failure to develop highly sensitive screening tests have led some physicians to recommend prophylactic oophorectomies to…

Eighty-four women at high risk for ovarian cancer by having first-degree relatives with epithelial ovarian cancer participated in a newly established, early ovarian cancer detection program at Yale University. Participants were to be evalua…