Diane Provencher — Endo Lab

other 2017

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

Nature genetics ·doi:10.1038/ng.3849

We studied the whole-genome point mutation and structural variation patterns of 133 tumors (59 high-grade serous (HGSC), 35 clear cell (CCOC), 29 endometrioid (ENOC), and 10 adult granulosa cell (GCT)) as a substrate for class discovery in …

article 2015

The ARID1A pathway in ovarian clear cell and endometrioid carcinoma, contiguous endometriosis, and benign endometriosis

International Journal of Gynecology & Obstetrics ·doi:10.1016/j.ijgo.2015.02.021

OBJECTIVE: To assess ARID1A-encoded protein (BAF250a) and phosphorylated AKT (pAKT) expression, apoptosis, and the DNA damage response pathway in endometrioid and clear cell ovarian cancers (endometriosis-associated ovarian cancers [EAOCs])…

article 2012

Combination of Serum Biomarkers to Differentiate Malignant From Benign Ovarian Tumours

·doi:10.1016/s1701-2163(16)35273-2

ObjectiveTo investigate biomarkers and clinical parameters to distinguish ovarian cancers from benign ovarian tumours.MethodsSerum biomarkers (CA 125, human epididymis protein 4 [HE 4], interleukin-18 [IL-18], leptin, macrophage migration i…

article 2010

Authors' Reply

·doi:10.1002/path.2740

We are pleased to respond to the interesting comments of Dr Stewart concerning the molecular subtyping of ovarian endometrioid carcinomas. We recently published a study on epithelial ovarian cancer in which we concluded that a number of hig…

article 2010

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

New England Journal of Medicine ·doi:10.1056/nejmoa1008433

BACKGROUND: Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis, but the molecular events involved in this transformation have not been described. METHODS: We sequenced the whole transcriptomes of 18 ovarian clear-ce…