Ya-Li Li

BACKGROUND: Endometriosis (EMs) is a common gynecological disorder characterized by endometrial-like tissue outside the uterus. Hypoxia induces the expression of many important downstream genes to regulate the implantation, survival, and ma…

OBJECTIVE: To determine the effects of hypobaric hypoxia pretreatment on surgically induced endometriosis in rats. METHODS: ) for 8 h. The uterine endometrium was intraperitoneally implanted into estrogen-treated ovariectomized Lewis rat, a…

OBJECTIVE: To determine ATPase inhibitory factor 1 (IF1) expression in normal and pathological tissue of female reproductive system to better understand the physiological role of IF1 in malignancies of the female reproductive system. METHO…

OBJECTIVE: To investigate the expression of the anti-oncogene ARHI in the endometriotic tissue and explore its clinical significance. METHODS: A semiquantitative analysis of the expression of ARHI mRNA and protein in the ectopic and eutopic…

OBJECTIVE: To establish a diagnostic model of endometriosis by analyzing serum peptidome patterns in patients with endometriosis using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS). METHODS: Ser…

OBJECTIVE: To investigate the distribution of ER isoforms in endometriosis and eutopic endometrium. METHODS: Tissue samples of patients with ovarian endometriosis, treated in People's Liberation Army General Hospital from January 2004 to De…

BACKGROUND: Direct and indirect evidences have suggested that angiogenesis is a prerequisite for the development of endometriosis. Aiming at offering experimental evidences for anti-angiogenesis therapy, we transplanted the eutopic endometr…

OBJECTIVE: To explore the potential use of integrin av beta3 (Lm609) monoclonal antibody against ectopic lesion and microvessel angiogenesis of human endometriosis xenografts in SCID mice. METHODS: The endometrial tissues from endometriosis…

OBJECTIVE: To study the role of hepatocyte growth factor (HGF) and its receptor (c-Met) in the pathogenesis of endometriosis. METHODS: In situ hybridization and immunohistochemistry method was used to examine HGF mRNA and protein expression…

Scatter factor (hepatocyte growth factor, SF/HGF) is a multifunctional polypeptide growth factor that plays an important role in tumor proliferation, angiogenesis and invasiveness. The aim of this study was to investigate the role of HGF in…

OBJECTIVE: To establish animal models of endometriosis in rhesus monkeys and study the invasion mechanism of endometriosis. METHODS: Five female healthy rhesus monkeys with regular menstrual cycles were selected, of whom 4 were used for end…