Manuel Stucki

ORCID: 0000-0002-9974-0134 · 1 paper in corpus

article 2019

Doxycycline reduces MMP-2 activity and inhibits invasion of 12Z epithelial endometriotic cells as well as MMP-2 and -9 activity in primary endometriotic stromal cells in vitro

Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-019-0481-z

BACKGROUND: Matrix metalloproteinases (MMPs), especially the gelatinases MMP-2 and MMP-9, play a crucial role in the pathogenesis of endometriosis by enabling invasion. Doxycycline is a well-tolerated antibiotic and a potent MMP-inhibitor i…