Wang H

ObjectiveThe study systematically examines the long-term trends in the global burden of Polycystic ovary syndrome (PCOS) across 204 countries and territories, with a specific focus on comparing pre-pandemic (1990-2019) and post-pandemic (20…

BACKGROUND: Endometriosis (EMS) is an estrogen-dependent disease that can lead to chronic pain and infertility. Small ubiquitin-related modifier (SUMO)ylation, a key post-translational modification, has been demonstrated to be associated wi…

BACKGROUND: Adenomyosis (AM) is described as a benign invasion of the endometrium into the myometrium, which impacts a large number of childbearing age women. The diagnosis of AM relies on imaging and histological examinations. Although car…

Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo exper…

BackgroundChronic endometritis (CE), characterized by CD138+ plasma cell infiltration, has been proposed to impair reproductive outcomes in assisted reproductive technology (ART). However, current evidence remains inconsistent, and diagnost…

ObjectiveThis study aimed to explore the diagnosis and treatment of patients who have reached menarche but present with clinical manifestations of genital tract obstruction.MethodsA retrospective analysis was conducted on 72 patients with a…

Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent and associated with metabolic dysfunction, systemic inflammation, and increased cardiovascular risk. The C-reactive protein-Triglyceride-Glucose Index (CTI…

Although Myo-Inositol/D-Chiro-Inositol (Ins) and berberine (BBR) have each shown beneficial effects in polycystic ovary syndrome (PCOS), their combined therapeutic potential has not been systematically evaluated. Here, we demonstrate that I…

BACKGROUND: The optimal surgical approach for reconstructing abdominal wall defects after radical resection of abdominal wall endometriosis (AWE) remains debated. This study aimed to compare the perioperative safety, recovery outcomes, and …

BACKGROUND: Endometriosis is a chronic inflammatory disease characterized by immune microenvironment dysregulation, with the IL-33/ST2L signaling axis playing a crucial role in macrophage polarization and disease progression. Despite growin…

Endometriosis (EMs) is a prevalent gynecological disorder affecting reproductive-age women. Exosomes secreted by peripheral blood macrophages may participate in EMs progression. In this pilot translational study, exosomes from peripheral bl…

We report a rare case of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome accompanied by simultaneous adenomyosis and leiomyoma in rudimentary uterine remnants. A 35-year-old woman presented with progressive lower abdominal pain and underwent…

Ovarian senescence is accompanied by inflammatory responses, yet the underlying mechanism remains incompletely elucidated. In this study, transcriptome sequencing was performed on ovarian granulosa cells from advanced-age patients and norma…

Phthalates (PAEs), typical endocrine-disrupting chemicals (EDCs) that accumulate in the human body to induce reproductive toxicity, have epidemiological links to endometriosis (EM), but the underlying micro-mechanisms remain unclear. Ferrop…

Metabolic determinants of oocyte quality and embryonic development remain incompletely understood. Here, we profiled metabolites in human cumulus cells (CCs) and follicular fluid (FF), validated in two mouse models, and integrated transcrip…

Ying Tang,1,2,* Hua-Dong Tian,1,* Xiao-Mei Chen,1,* Hang Wang,3,* Li-Ming Shen,1 Shang-Qi Ni,1 Bin Su,1 Zhi-Jun Jiang,4 Li-Juan Zhu,4 Yue-Xi Luo,1 Qiuling Shi2 1Department of Obstetrics and Gynecology, The Affiliated Nanchon…

BACKGROUND: The underlying mechanisms of symptom recurrence or established comprehensive predictive models have not yet elucidated. This study aimed to establish a prediction model for symptom recurrence following focused ultrasound ablatio…

Infertility represents a significant global health burden, necessitating advanced therapeutic interventions. While Assisted Reproductive Technologies have revolutionized fertility treatment, they remain constrained by limited efficacy, off-…

Endometriosis (EMs) features ectopic implantation of endometrial stromal cells (EESCs) and strong anoikis resistance, yet how inflammatory signals reprogram mitochondrial function remains unclear. Here, neutrophil extracellular traps (NETs)…

Uterine infertility is a substantial global health challenge, imposing profound physical and emotional burdens on affected individuals, with endometrial injury being a key contributing factor. In this study, we report that platelet-derived …

Endometrioid carcinoma is one of the most prevalent malignant neoplasms in gynecology, in contrast to perivascular epithelioid cell tumor (PEComa), a rare stromal tumor, which is seldom encountered in the female genital system. The coexiste…

BackgroundThe copper intrauterine device (Cu-IUD) is a widely used long-term contraceptive method. However, whether prior Cu-IUD use, including long-term exposure, affects reproductive and neonatal outcomes after assisted reproductive techn…

Calcitonin gene-related peptide (CGRP), a neuropeptide, has been implicated in autoimmune diseases, endometriosis, tumors, and primary headaches, including migraine. The development of a novel, fast-acting CGRP receptor antagonist administe…

BackgroundEndometrial fibrosis can disrupt the uterine junctional zone and lead to infertility. Accurate and noninvasive evaluation of junctional zone alterations is important to clinical treatment. Although conventional T2-weighted imaging…

Endometriosis-associated ovarian cancer (EAOC) is a rare subtype of ovarian cancer arising from the malignant transformation of endometriosis (EMS). Despite growing clinical awareness, its underlying pathogenic mechanisms are not fully unde…