Sijia Wang

ORCID: 0009-0002-9881-4290 · 5 papers in corpus
article 2025
The Therapeutic Potential of EGCG and Pro-EGCG in Mitigating Ovarian Hyperstimulation Syndrome: Unraveling the Modulatory Mechanism through the VEGF Pathway
International journal of biological sciences ·doi:10.7150/ijbs.98653

Ovarian hyperstimulation syndrome (OHSS) is a severe complication of controlled ovarian hyperstimulation (COH) during in vitro fertilization (IVF) treatment, characterized by increased capillary permeability.Vascular endothelial growth fact…

review 2022
Myostatin: a multifunctional role in human female reproduction and fertility – a short review
Reproductive biology and endocrinology : RB&E ·doi:10.1186/s12958-022-00969-4

Myostatin (MSTN) is member of the transforming growth factor β (TGF-β) superfamily and was originally identified in the musculoskeletal system as a negative regulator of skeletal muscle growth. The functional roles of MSTN outside of the mu…

2021
High ovarian GDF-8 levels contribute to elevated estradiol production in ovarian hyperstimulation syndrome by stimulating aromatase expression.
International journal of biological sciences ·doi:10.7150/ijbs.60332

Rationale: Growth differentiation factor-8 (GDF-8), also known as myostatin, belongs to the transforming growth factor-beta (TGF-β) superfamily. GDF-8 is expressed in the ovary and regulates various ovarian functions. Ovarian hyperstimulati…

article 2020
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental & molecular medicine ·doi:10.1038/s12276-020-0396-y

Ovarian hyperstimulation syndrome (OHSS) is one of the most serious and iatrogenic complications that can occur during in vitro fertilization treatment. Although the pathogenesis of OHSS is not fully understood, vascular endothelial growth …

2019
Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression.
Aging ·doi:10.18632/aging.102367

Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Melatonin and its receptors are expressed in human granulosa cells, and have been shown to influence b…