Nomikos M

ORCID: 0000-0001-9761-6327 · 1 paper in corpus

2026

Pathogenic homozygous PLCZ1 mutation reduces sperm protein levels with a simulated reduction of PIP2 binding: a case report.

Reproduction & fertility ·doi:10.1530/raf-25-0085

AbstractMammalian oocyte activation is driven by intracellular calcium (Ca2+) oscillations induced by sperm-specific phospholipase C zeta (PLCζ). Sperm PLCζ deficiency is linked to male infertility caused by oocyte activation deficiency. Us…