HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expressi…
Infertility is an area of increasing in life science research. Although follicular maturation disorders and anovulation are the primary causations of infertility, its molecular mechanism is not well understood. Recent research has shown tha…
ObjectiveTo estimate the influence of prior oral contraceptive pill (OCP) use on future diagnosis of endometriosis in young women.DesignProspective cohort study, the Australian Longitudinal Study on Women's Health.SettingCommunity-based sam…
OBJECTIVE: To investigate the expression and role of oxidative stress markers in the serum and follicular fluid of patients with endometriosis. MATERIALS AND METHODS: A prospective case-control study was conducted in 42 patients who underw…
PURPOSE OF REVIEW: To review the latest developments in reproductive tract stem cell biology. RECENT FINDINGS: In 2004, two studies indicated that ovaries contain stem cells which form oocytes in adults and that can be cultured in vitro in…
Several recent findings in stem cell biology have resulted in new opportunities for the treatment of reproductive disease. Endometrial regeneration can be driven by bone marrow derived stem cells. This finding has potential implications for…
Calpains have been implicated in the regulation of apoptosis. Here, we identified Calpain5 as a target of HOXA10 transcriptional regulation in endometrial cells as well as its aberrant regulation in endometriosis. Histologically confirmed b…
The eutopic endometrium in women with endometriosis demonstrates diminished endometrial receptivity and altered gene expression. It is unknown if the endometrium being defective gives rise to a predisposition toward endometriosis and infert…
Bone marrow-derived cells (BMDCs) can differentiate into nonhematopoietic cells, suggesting that BMDCs may contribute to the maintenance of multiple tissues. Donor-derived bone marrow cells have been identified in human uterine endometrium.…