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BackgroundPreeclampsia (PE) is a significant complication of pregnancy, and its association with in vitro fertilization (IVF) remains unclear, especially across different demographic groups.MethodsWe conducted a retrospective multicenter co…

Deep infiltrating endometriosis (DIE) is a severe form of endometriosis that rarely undergoes malignant transformation, and when it does, diagnosis is often difficult. Here, we report two cases of long-standing DIE that progressed to endome…

ObjectiveTo investigate whether prolonged embryo culture increases the risk of gestational diabetes mellitus (GDM) in pregnancies conceived via frozen embryo transfer (FET).Research design and methodsIn this retrospective cohort study, 26 1…

Recurrent implantation failure (RIF), characterized by repeated failure to achieve clinical pregnancy after embryo transfer, is often associated with abnormal endometrial conditions. However, unexplained RIF is unique in that its underlying…

Cavernous sinus dural arteriovenous fistula (CS-DAVF) is a rare vascular disorder, with clinical manifestations largely determined by venous drainage patterns. Conventional endovascular treatment via the inferior petrosal sinus or superior …

Emerging evidence implicates per- and polyfluoroalkyl substances (PFAS) in adverse alterations to the follicular microenvironment, yet their potential contribution to diminished ovarian reserve (DOR) remains poorly characterized. This study…

BackgroundThe clinical benefit of immunotherapy in ovarian cancer (OC) remains limited. The primary reason is not simply a lack of immune activation, but rather the marked spatiotemporal heterogeneity of the tumour immune microenvironment. …

Preeclampsia is a leading cause of maternal and neonatal morbidity and mortality, affecting 3 to 8% of pregnancies. Currently, no clinically useful predictive biomarker exists. Preeclampsia is characterised by systemic inflammatory response…

BackgroundThe clinical efficacy of antioxidants in assisted reproductive technology (ART) remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impact of oral antioxidant supplementation on reproductive outcom…

BackgroundUreteral reimplantation (UR) is the standard treatment for distal ureteral stricture, yet postoperative anastomotic restenosis impairs outcomes, with conventional imaging unable to quantify urinary tract obstruction and dysfunctio…

BackgroundProtein palmitoylation is a significant post-translational modification that influences protein stability, localization, and signaling through the addition of palmitoyl groups to cysteine, serine/threonine, or lysine residues. It …

Following the initial treatment of nasopharyngeal carcinoma (NPC), tumor progression often portends an adverse prognosis for these patients. MicroRNAs (miRNAs) have emerged as critical regulators of tumor immunity, yet their intricate mecha…

OBJECTIVE: To compare the short-term effects of dienogest and oral contraceptives (OCPs) on pain and quality of life in women with endometriosis. METHOD: The databases including PubMed, Cochrane Library, Embase, Web of Science, CNKI, and W…

Recurrent miscarriage (RM) is currently difficult to prevent and treat due to a lack of comprehensive understanding of its molecular mechanisms. The aim of this study was to identify genes potentially involved in the pathogenesis of RM and …

Primary dysmenorrhea (PD) is one of the common gynaecological disorders, which significantly affects the physical and mental health of women of reproductive age. Shenghua Decoction (SHD) is a classic formula for treating gynaecological diso…

Ovarian cancer ranks as the eighth most common malignancy in women globally. Early detection remains a critical challenge for improving ovarian cancer diagnosis and treatment outcomes. Our prior study demonstrated that ARHGAP40 downregulati…

BackgroundAlthough many studies have validated the diagnostic performance of Ovarian-Adnexal Reporting and Data Systems ultrasound (O-‎RADS US), most have been observed by experienced sonologists, and relatively few by junior sonologists. T…

BackgroundInflammatory Bowel Disease (IBD) is a chronic, idiopathic inflammatory disorder of the intestines. Oxymatrine (OMT) is a naturally active substance found in the desiccated roots of Sophora flavescens. It possesses anti-tumor, anti…

BACKGROUND: Endometriosis (EMs) is a common condition that causes dysmenorrhea, chronic pelvic pain, and infertility, affecting millions of women worldwide. Despite the use of assisted reproductive technology, EMs patients often experience …

Endometriosis is a chronic inflammatory condition, typically associated with pelvic pain and menorrhagia, affecting 10% of women of reproductive age. Inflammation is known to contribute to pregnancy complications, including preterm birth. R…

BackgroundHereditary primary hyperparathyroidism (PHPT) accounts for 5-10% of all PHPT cases, necessitating genetic testing for diagnosis and management. Among these, hyperparathyroidism-jaw tumor syndrome (HPT-JT) is an autosomal dominant …

IntroductionThe prevention of unintended pregnancy is a public health issue affecting women worldwide. In Australia, women are required to get a prescription to obtain the oral contraceptive pill (OCP), which may limit access and be a barri…

OBJECTIVE: To assess the association between adenomyosis volume, as a reflection of its severity, and the risk of adverse perinatal outcomes. METHODS: This multicenter retrospective cohort study was conducted at a comprehensive tertiary ca…

Ferroptosis, caused by disorders of iron metabolism, plays a critical role in various diseases, making the regulation of iron metabolism essential for tissue repair. In our analysis of degenerated intervertebral disc tissue, we observe a po…

BackgroundFemale fertility declines with increased maternal age, and this decline is even more rapid after the age of 35 years. Follicular fluid (FF) is a crucial microenvironment that plays a significant role in the development of oocytes,…