Jeffrey C Pelletier

No ORCID on file · 3 papers in corpus · active 2003-2010

Study types

  • other 2
  • review 1

Condition tags

  • endometriosis 3
other 2010
Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor
Bioorganic & medicinal chemistry letters ·doi:10.1016/j.bmcl.2010.02.099

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH anta…

other 2008
2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor
Bioorganic & medicinal chemistry ·doi:10.1016/j.bmc.2008.05.024

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has shown positive clinical results in numerous reproductive tissue disorders such as endometriosis, prostate cancer and others. Traditional therapy has been limited to peptid…

review 2003
GnRH agonists and antagonists in cancer therapy
Current medicinal chemistry. Anti-cancer agents ·doi:10.2174/1568011033482251

Gonadotropin releasing hormone (GnRH) is a hypothalamic decapeptide that binds to GnRH receptors on pituitary gonadotrope cells to modulate the synthesis and secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating …