Huang Y

PURPOSE: Endometriosis (EM) and recurrent spontaneous abortion (RSA) exhibit clinical associations, yet their shared molecular mechanisms remain unclear. This study aimed to identify shared molecular mechanisms and potential hub genes under…

BACKGROUND: Cryoablation is a minimally invasive treatment, with limited research on uterine diseases. This paper provides a review of image-guided cryoablation for the treatment of gynecologic diseases, such as uterine myoma, abdominal wal…

OBJECTIVE: IVF/ICSI is associated with an increased risk of placenta accreta spectrum disorders (PAS). Invasive PAS can result in significant adverse maternal and fetal outcomes. This study investigates the impact of IVF/ICSI on the severit…

OBJECTIVE: To evaluate the effect of prior uterine cavity procedures on clinical and neonatal outcomes in patients undergoing first-time in vitro fertilization-embryo transfer with donor sperm (IVF-ET with DS). METHODS: This retrospective …

BACKGROUND: Adenomyosis is a common gynecological condition associated with chronic pelvic pain, menorrhagia, and infertility. High-intensity focused ultrasound (HIFU) has gained attention as a noninvasive treatment modality. However, monot…

Cancer remains the leading cause of mortality worldwide, and the emergence of drug resistance has made the identification of new therapeutic targets imperative. Lactate, traditionally viewed as a byproduct of glycolysis with limited ATP-pro…

RATIONALE: Adenomyoma of the broad ligament is rare. Owing to the absence of typical clinical signs and imaging methods, preoperative diagnosis is challenging, and it is mainly diagnosed through surgical pathology. PATIENT CONCERNS: The pa…

Endometriosis has been increasingly associated with the aberrant regulation of non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). Despite the growing recognition of their biological significance, t…

Appendiceal mucocele (AM) is characterized by the dilation of the appendix due to the accumulation of mucinous material within its lumen, often discovered incidentally on imaging. Symptoms of AM are typically nonspecific or absent, but pati…

Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications. However, the role of protein palmitoylation in oocyte aging ha…

Macrophages are vital sentinels in innate immunity, and their functions cannot be performed without internal metabolic reprogramming. Mitochondrial dynamics, especially mitochondrial fusion and fission, contributes to the maintenance of mit…

ObjectiveEffective early diagnosis and timely intervention in acute pancreatitis (AP) are essential for improving patient outcomes. This study aims to evaluate the clinical utility of the neutrophil CD64 index (nCD64) in stratifying patient…

PURPOSE: This study aimed to investigate the impact of obstructive sleep apnea (OSA) on in vitro fertilization (IVF) and embryo transfer outcomes in infertile patients with polycystic ovary syndrome (PCOS). METHODS: We conducted a prospect…

IntroductionUterine sarcoma (US) is a rare tumor characterized by high aggressiveness, a tendency for recurrence and distant metastasis, and an extremely poor prognosis. In this study, we evaluated the expression of Orosomucoid 1 (ORM1) in …

BACKGROUND: Fear of childbirth is a common concern among pregnant women, potentially affecting maternal physical and mental health as well as birth outcomes. However, the factors influencing fear of childbirth are still being explored. This…

Peptide- and protein-based therapeutics offer realized and potential benefits to health, due to their potent bioactivity, high specificity, and favorable safety characteristics. However, their widespread clinical application is constrained …

Organoids are three-dimensional tissue analogues grown in vitro. Although they are not human organs in the strict sense, they can mimic the structure and function of tissues in vivo to the maximum extent, and have broad application prospect…

Endometriosis is a chronic inflammatory disease that primarily affects women of reproductive age. The current hormonal treatments are unsuitable for women who wish to conceive, highlighting the need for non-hormonal therapeutic alternatives…

Tubal ciliary movement is one of the essential transport mechanisms for female fertility, playing a key role in facilitating oocyte pickup and transporting the fertilized ovum. This movement is mediated by multiciliated cells and regulated …

BACKGROUND: Ureteral reimplantation plays a crucial role in distal ureteral reconstruction, and the integration of robotic systems has greatly enhanced minimally invasive surgical techniques. This pilot study aims to evaluate the technicall…

Peripheral nerve injury-induced muscle atrophy is characterized by chronic inflammation and dysregulated macrophage polarization. RUNX1, a transcription factor upregulated in denervated muscle, has been implicated in linking muscle degenera…

OBJECTIVE: This study explored the incidence of adverse events (AEs) following microwave ablation (MWA) under local anesthesia and analyzed factors related to benign uterine diseases, including uterine fibroids (UFs) and adenomyosis (AM). …

Endometriosis involves ectopic growth of endometrial-like tissue, yet the spatial transcriptomic and metabolic landscape of ovarian endometriomas remains poorly understood. This investigation presents a comprehensive multi-omics analysis of…

Through a combination of single-cell/single-nucleus RNA-Seq (sc/snRNA-Seq) data analysis, immunohistochemistry, and primary macrophage studies, we have identified pathogenic macrophages characterized by Tet methylcytosine dioxygenase 3 (TET…

BACKGROUND: Shear wave elastography (SWE) can be used to detect the stiffness of the myometrium and lesion of the uterus, shear wave dispersion (SWD) can be used to detect the viscoelasticity, and magnetic resonance imaging (MRI) can be use…