Carlo C. Maley

Adaptive therapy, as per the dose modulation, dose-skipping, or intermittent treatment protocol works well for treatment using a single cytotoxic drug, under a wide range of scenarios and parameter settings. In contrast, adaptive therapy wo…

Abstract While the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant tissues that progress to cancer compared to those that remain cancer-free. …