Pedersen NL — Endo Lab

2024

Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.

Human reproduction (Oxford, England) ·doi:10.1093/humrep/dead247

Study questionWhich genetic factors regulate female propensity for giving birth to spontaneous dizygotic (DZ) twins?Summary answerWe identified four new loci, GNRH1, FSHR, ZFPM1, and IPO8, in addition to previously identified loci, FSHB and…

2016

Somatic Comorbidity in Women with Overactive Bladder Syndrome.

The Journal of urology ·doi:10.1016/j.juro.2016.02.076

PurposeWe explore the influence of co-occurring somatic illnesses on prevalent overactive bladder in women of premenopausal age.Materials and methodsData for the present study were derived from a nationwide survey on complex diseases among …

2015

New genetic loci link adipose and insulin biology to body fat distribution.

Nature ·doi:10.1038/nature14132

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links…

2013

Germline genetic contributions to risk for esophageal adenocarcinoma, Barrett's esophagus, and gastroesophageal reflux.

Journal of the National Cancer Institute ·doi:10.1093/jnci/djt303

BackgroundEsophageal adenocarcinoma (EA) is an increasingly common cancer with poor survival. Barrett's esophagus (BE) is the main precursor to EA, and every year 0.12% to 0.5% of BE patients progress to EA. BE typically arises on a backgro…

2011

Influence of smoking, coffee, and tea consumption on bladder pain syndrome in female twins.

Urology ·doi:10.1016/j.urology.2010.12.072

ObjectivesTo assess the influence of smoking, coffee and tea consumption on the risk for bladder pain syndrome (BPS) using the O'Leary Interstitial Cystitis Symptom Index (ICSI).MethodsIn 2005, all twins born between 1959 and 1985 in Sweden…