Liu R

PURPOSE: To identify the specific risk factors associated with unexplained infertility (UI) among infertile couples. METHODS: We conducted a retrospective cohort study analyzing UI risk factors, focusing on 5465 infertile couples who compl…

We report a rare case of sporadic cervical clear cell adenocarcinoma (CCAC) in a 46-year-old perimenopausal woman without the classic risk factors of in utero diethylstilbestrol (DES) exposure or high-risk human papillomavirus (HPV) infecti…

Accumulating observational evidence suggests an association between thyroid function and endometriosis, though the causal relationship remains unclear. To investigate potential bidirectional causal relationships, including for endometriosis…

OBJECTIVE: To identify independent risk factors for fertilization failure (FF) during conventional in vitro fertilization (IVF) and to develop a predictive model for clinical risk stratification. METHODS: This retrospective study included …

BACKGROUND: Endometriosis (EM) is a chronic inflammatory gynaecological disorder affecting approximately 10% of women of reproductive age. Early diagnosis remains challenging because definitive diagnosis still relies on invasive surgical co…

Infertility represents a significant global health burden, necessitating advanced therapeutic interventions. While Assisted Reproductive Technologies have revolutionized fertility treatment, they remain constrained by limited efficacy, off-…

Endometriosis is a common, chronic gynecological disorder characterized by the presence of endometrial-like tissue outside the uterine cavity, frequently associated with significant morbidities such as pelvic pain and infertility. Elucidati…

Panax ginseng C.A. Meyer, a renowned medicinal herb, exerts many of its systemic effects through intricate interactions with the gut microbiota, a relationship that also addresses the challenge of its own limited oral bioavailability. This …

Fisetin, a flavonoid widely present in natural plants, exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, anti-apoptotic, and anti-aging effects. Its protective roles within the mammalian reproductive syst…

PURPOSE: To systematically conduct a retrospective summary of the optimal surgical strategies and techniques for managing various types of unilateral genital tract obstruction with ipsilateral renal anomaly (UGTOIRA) syndrome, and to establ…

Repeated implantation failure (RIF) presents a significant challenge to in vitro fertilization (IVF), and abnormalities in the endometrium often play a crucial role in RIF. To enhance and deepen our understanding of tissue context in the en…

OBJECTIVE: Although numerous observational studies have revealed a correlation between leukocyte telomere length (LTL) and female reproductive system diseases (RSDs), the findings of these studies have tended to be consistent. In this study…

OBJECTIVE: To evaluate the efficacy and safety of the Peiyu Granules (PYG) compared with placebo on early miscarriage rates among women undergoing embryo transfer. METHODS: A double-blind, parallel-group randomized clinical trial between F…

BACKGROUND: Ovarian cancer is a highly lethal gynecological malignancy, with epithelial ovarian cancer (EOC) being its most common form. Surgery combined with chemotherapy is the standard treatment. Resection completeness significantly impa…

PURPOSE: For unexpected low-prognosis patients (Group 1 and Group 2) defined by POSEIDON criteria, how to maximize the live birth rate while controlling the multiple birth rate by tailoring the embryo transfer number and quality? METHODS: …

CXC chemokine ligand 8 (CXCL8) has emerged as a critical mediator in tumorigenesis. This study aims to elucidate the role of CXCL8 in the initiation and progression of papillary thyroid carcinoma (PTC). Comprehensive bioinformatic analyses …

OBJECTIVE: To explore the influencing factors of polyspermy in long-term fertilization during in vitro fertilization (IVF) with antagonist protocol. METHODS: This was a retrospective case-control study. Patients with secondary infertility …

Endometrial carcinoma (EC) is a common malignancy of the female reproductive system, often diagnosed at advanced stages due to the lack of reliable early biomarkers. Gene methylation has emerged as a key epigenetic mechanism in cancer devel…

OBJECTIVE: The impact of prophylactic salpingectomy on the prevention of epithelial ovarian cancer (EOC) remains unclear, particularly in Asian populations where data is lacking. In this systematic review and meta-analysis study, we sought …

OBJECTIVES: To analyze clinical outcomes and the factors that influence the therapeutic outcomes of high-intensity focused ultrasound (HIFU) ablation for different types of submucosal uterine fibroids. MATERIALS AND METHODS: A total of 626…

Ethnopharmacological relevance: Pelvic inflammatory disease (PID) is a frequently occurring gynecological disorder mainly caused by the inflammation of a woman's upper genital tract. Generally, antibiotics are used for treating PID, but pro…

OBJECTIVE: To explore the choice of embryo transfer schemes for patients with low oocyte retrieval (≤ 3 oocytes). METHODS: A retrospective analysis was conducted on patients with oocyte yields ≤ 3 undergoing in vitro fertilization and embr…

RATIONALE: Intravascular/intravenous leiomyomatosis (IVL) is a peculiar variant of uterine leiomyoma that is classified as a histologically benign smooth muscle tumor with a biological behavior similar to that of a malignant tumor. It is ch…

OBJECTIVE: We aimed to analyze the effect of high-intensity focused ultrasound (HIFU) on different types of adenomyosis (AM) based on magnetic resonance imaging (MRI) classification. METHODS: A total of 206 AM patients who underwent HIFU b…

Endometriosis, often associated with chronic pelvic pain, can lead to anxiety and depression. This study investigates the role and mechanism of Glycine receptor alpha 3 (Glrα3) in the central sensitization of pain in endometriosis, aiming t…