Meng TG

ORCID: 0000-0001-8069-0256 · 3 papers in corpus
lab-animal 2026
Cuproptosis causes meiotic metaphase I arrest by disrupting mitochondrial functions in oocytes
Cell death discovery ·doi:10.1038/s41420-026-03168-x

Proper oocyte maturation is critical for female fertility, yet whether cuproptosis, a recently identified copper-dependent cell death pathway, affects meiotic maturation remains unknown. Here, we show that Cu(II)-elesclomol (ELC-Cu(II)) tre…

lab-animal 2026
The dynamic landscape and conserved regulation of the m6Am and m6A methylomes during the human and mouse oocyte-to-embryo transition
Nucleic acids research ·doi:10.1093/nar/gkag103

N 6-methyladenosine (m6A) and N6, 2'-O-dimethyladenosine (m6Am) are two RNA modifications that play essential roles in diverse RNA metabolic processes and functions. Despite their importance, the dynamic landscapes and regulatory patterns o…

lab-animal 2018
Mitochondrial regulation of [Ca2+]i oscillations during cell cycle resumption of the second meiosis of oocyte
Cell cycle (Georgetown, Tex.) ·doi:10.1080/15384101.2018.1489179

Oocyte is arrested at metaphase of the second meiosis until fertilization switching on [Ca2+]i oscillations. Oocyte activation inefficiency is the most challenging problem for failed fertilization and embryonic development. Mitochondrial fu…