Egbuta C

No ORCID on file · 2 papers in corpus · active 2012-2016
2016
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Journal of medicinal chemistry ·doi:10.1021/acs.jmedchem.5b01281

Human aromatase catalyzes the synthesis of estrogen from androgen with high substrate specificity. For the past 40 years, aromatase has been a target of intense inhibitor discovery research for the prevention and treatment of estrogen-depen…

2012
Novel aromatase inhibitors by structure-guided design.
Journal of medicinal chemistry ·doi:10.1021/jm300930n

Human cytochrome P450 aromatase catalyzes with high specificity the synthesis of estrogens from androgens. Aromatase inhibitors (AIs) such as exemestane, 6-methylideneandrosta-1,4-diene-3,17-dione, are preeminent drugs for the treatment of …