Peng J

Chronic endometritis (CE) is a plasma cell-related endometrial inflammatory phenotype that may compromise fertility, while endometriosis (EM) is an immune-mediated inflammatory disorder. However, whether EM is associated with CD138-defined …

BACKGROUND: Adenomyosis is commonly associated with dysmenorrhea and heavy menstrual bleeding. Although the levonorgestrel-releasing intrauterine system (Mirena, LNG-IUS) is recommended as a first-line conservative treatment, device displac…

OBJECTIVE: Polycystic ovary syndrome (PCOS) is a leading cause of female infertility, and early pregnancy outcomes in affected women are affected by multiple interactive factors; however, no well-established predictive tools are available. …

BACKGROUND: Laparoscopic ethanol sclerotherapy is a fertility-preserving alternative for ovarian endometriomas, but the appropriate ethanol exposure duration remains uncertain. We compared expectant management with 5- and 15-minute ethanol …

STUDY OBJECTIVE: To compare the safety and efficacy of laparoscopic versus transvaginal ethanol sclerotherapy in patients with ovarian endometriomas (OEMs). DESIGN: Preliminary retrospective cohort study. SETTING: Reproductive Medicine Re…

Endometriosis is a benign yet invasive disease characterized by ectopic endometrial growth and immune remodeling. While emerging evidence implicates cellular senescence in disease progression, the underlying mechanisms remain largely undefi…

STUDY OBJECTIVE: To evaluate the effects of a 3-stage treatment strategy featured by cold-knife adenomyomectomy, enhanced endometrial protection and postoperative uterine monitoring for severe diffuse adenomyosis on IVF/ICSI and perinatal o…

PURPOSE: To compare the effects of the gonadotrophin-releasing hormone (GnRH) agonist protocol, GnRH antagonist protocol, progestin-primed ovarian stimulation (PPOS) protocol, and mild stimulation/natural cycle protocol on the cumulative li…

BACKGROUND AND AIMS: Due to its association with various diseases, atherogenic index of plasma (AIP) has garnered increasing attention. Exploration of the relationship between AIP and endometriosis risk has not been thorough. This nationwid…

Liwen Liu,1 Gaosheng Su,1 Jie Rao,1 Juanbao Peng,1 Xiu Lin,2 Yujie Huang,2 Feng Liang,2 Chuanxia Feng,1 Zhong Lin2 1Department of Anesthesia, The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People’s Republic…

Excessive androgens may lead to abnormal folliculogenesis and anovulation. To explore the link between hyperandrogenism (HA) and anovulation - related infertility, we performed a two - sample Mendelian randomization analysis, followed by mu…

BACKGROUND: Hyperuricemia (HUA) impairs sperm function via oxidative stress and metabolic dysregulation. This retrospective cohort study aimed to investigate the therapeutic effect of density gradient centrifugation (DGC) on HUA-associated …

STUDY QUESTION: Can harmine mitigate endometriosis by modulating oxidative phosphorylation (OXPHOS) suppression and macrophage polarization? SUMMARY ANSWER: Harmine induces apoptosis in endometriotic lesions by inhibiting OXPHOS while also…

ETHNOPHARMACOLOGICAL RELEVANCE: Pingchong Jiangni recipe (PJR) is a Chinese herbal formula that has been used clinically for decades in the treatment of endometriosis, with effects such as shrinking the lesions and reducing the recurrence r…

Pingchong Jiangni recipe (PJR) is a Chinese herbal formula that has been used clinically for decades in the treatment of endometriosis, with effects such as shrinking the lesions and reducing the recurrence rate. However, the mechanisms und…

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that P…

BACKGROUND AND AIMS: This network meta-analysis aimed to compare the perioperative efficacy of various minimally invasive hysterectomy procedures for treating benign gynecological diseases and to assess whether vaginal natural orifice trans…

BACKGROUND: Endometriosis is a common gynecological disease that affects approximately 5 %∼10 % of reproductive-aged women. Zinc (Zn), selenium (Se), copper (Cu), cobalt (Co) and molybdenum (Mo) are essential trace elements and are very imp…

Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Despite of a steadily increasing in morbidity and mortality, there is still no effective therapy. Gut microbial dysbiosis and its derived-metabolites disorder have been sho…

BACKGROUND: Observational studies have explored the impact of iron homeostasis on infertility; however, establishing definitive causal relationships remains challenging. This study utilized a two-sample Mendelian randomization approach to i…

OBJECTIVE: To compare the application of sequential embryo transfer, cleavage embryo transfer, and blastocyst transfer combined with intrauterine perfusion in frozen-thawed embryo transfer cycles in patients with recurrent implantation fail…

Telomere attrition plays a critical role in the reproductive aging process in humans. Telomere length (TL) is typically regulated by telomerase, the main component of which is telomerase reverse transcriptase (TERT). The aim of the present …

BACKGROUND: Polycystic ovary syndrome (PCOS) is known to be associated with chronic low-grade inflammation and endometrial dysfunction. Chronic endometritis (CE) is a type of local inflammation that can contribute to endometrial dysfunction…

BACKGROUND: To evaluate the efficacy of the enhanced recovery after surgery (ERAS) programs on the systemic inflammatory response (SIR) of patients following gynecological surgery, a randomized controlled trial was performed to compare the …

Worrying trends of increased cardiovascular disease (CVD) risk in children, adolescents and young people in the Modern Era have channelled research and public health strategies to tackle this growing epidemic. However, there are still contr…