Tom Jansen

ORCID: 0000-0001-8006-8627 · 1 paper in corpus

2025

Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins.

mAbs ·doi:10.1080/19420862.2025.2553624

Antibodies that bind in a pH-dependent manner to their antigens show promise for enhanced neutralization potency and blocking capacity against extracellular targets. However, because the mechanisms governing pH-dependent antigen binding rem…