Cain KC

No ORCID on file · 10 papers in corpus · active 2009-2020

Condition tags

  • irritable_bowel_syndrome 10
2020
Relationships of Microbiome Markers With Extraintestinal, Psychological Distress and Gastrointestinal Symptoms, and Quality of Life in Women With Irritable Bowel Syndrome.
Journal of clinical gastroenterology ·doi:10.1097/mcg.0000000000001107

IntroductionAltered microbial diversity has been associated with gastrointestinal (GI) symptoms in persons with irritable bowel syndrome (IBS). Less is known about the relationship of microbiome with extraintestinal pain and psychological d…

2018
Stool and urine trefoil factor 3 levels: associations with symptoms, intestinal permeability, and microbial diversity in irritable bowel syndrome.
Beneficial microbes ·doi:10.3920/bm2017.0059

Previously we showed that urine trefoil factor 3 (TFF3) levels were higher in females with irritable bowel syndrome (IBS) compared to non-IBS females. To assess if TFF3 is associated with symptoms and/or reflect alterations in gastrointesti…

2016
Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome.
Biological research for nursing ·doi:10.1177/1099800416633296

Alterations in serotonin signaling are suspected in the pathophysiology of irritable bowel syndrome (IBS). By modulating the extracellular reuptake of serotonin, the serotonin transporter (SERT) acts as a key regulator of the bioavailabilit…

2014
Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome.
Journal of gastroenterology ·doi:10.1007/s00535-013-0919-6

BackgroundAlterations in gastrointestinal (GI) permeability and immune measures are present in some patients with irritable bowel syndrome (IBS) but the relationship to symptoms is poorly defined. In adults with IBS, we compared permeabilit…

2014
TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome.
Biological research for nursing ·doi:10.1177/1099800412466694

The aims of this exploratory study were to examine whether tryptophan hydroxylase (TPH) gene polymorphisms are associated with psychosocial factors in women with irritable bowel syndrome (IBS). TPH is the rate-limiting enzyme in the biosynt…

2011
Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome.
Neurogastroenterology and motility ·doi:10.1111/j.1365-2982.2010.01623.x

BackgroundAlterations in serotonin (5-HT) are suspected in the pathophysiology of irritable bowel syndrome (IBS). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: TPH1 and TPH2.…

2011
Does a self-management program change dietary intake in adults with irritable bowel syndrome?
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates ·doi:10.1097/sga.0b013e31821092e8

Making dietary changes such as increasing fiber intake is recommended for the management of irritable bowel syndrome symptoms. Few studies have explored the efficacy of education on compliance with recommendations such as increasing fiber, …

2011
Is childhood abuse or neglect associated with symptom reports and physiological measures in women with irritable bowel syndrome?
Biological research for nursing ·doi:10.1177/1099800410393274

PurposeEarly childhood traumatic experiences (e.g., abuse or neglect) may contribute to sleep disturbances as well as to other indicators of arousal in patients with irritable bowel syndrome (IBS). This study compared women with IBS positiv…

2011
Subtypes of irritable bowel syndrome based on abdominal pain/discomfort severity and bowel pattern.
Digestive diseases and sciences ·doi:10.1007/s10620-011-1567-4

IntroductionIrritable bowel syndrome (IBS) has traditionally been classified by stooling pattern (e.g., diarrhea-predominant). However, other patterns of symptoms have long been recognized, e.g., pain severity. Our objective was to examine …

2009
Comprehensive self-management for irritable bowel syndrome: randomized trial of in-person vs. combined in-person and telephone sessions.
The American journal of gastroenterology ·doi:10.1038/ajg.2009.479

ObjectivesPsychological and behavioral therapies are being increasingly used for symptom management in patients with irritable bowel syndrome (IBS). The aims of this study were to compare two delivery modes for a comprehensive self-manageme…