Eun‐Ju Lee — Endo Lab

2025

Human endogenous retrovirus-K envelope protein is aberrantly expressed in serous ovarian cancer and promotes chemosensitivity via NF-κB/P-glycoprotein pathway inhibition.

Journal of ovarian research ·doi:10.1186/s13048-025-01722-2

BackgroundApproximately 100,000 human endogenous retroviruses (HERV) are integrated into the human genome. Most HERVs are not expressed; however, transcription within the family HERV-K, a class II beta-retrovirus, occurs in specific cancers…

2023

High visceral fat-to-muscle ratio is an independent factor that predicts worse overall survival in patients with primary epithelial ovarian, fallopian tube, and peritoneal cancer.

Journal of ovarian research ·doi:10.1186/s13048-023-01098-1

BackgroundThe intra-abdominal cavity, surrounded by adipocytes, is the main metastatic site of epithelial ovarian, fallopian tube, and peritoneal cancer. Epidemiological and molecular studies have demonstrated a link between adipose tissue …

article 2016

Role of Hormone Therapy After Primary Surgery for Endometrioma: A Multicenter Retrospective Cohort Study

Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115625841

Endometriosis is a major cause of disability in women, and 40% to 50% of patients experience disease recurrence by 5 years after surgery. This multicenter retrospective cohort study (N = 588) determined the rate and risk factors for recurre…

article 2013

Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts

Molecular human reproduction ·doi:10.1093/molehr/gat091

Mammalian target of rapamycin (mTOR) is known to be a major negative regulator of autophagy. Recent studies have shown that mTOR activity is abnormally increased in endometriotic lesions. In endometriosis, abnormal mTOR activity may contrib…