Xu JN

No ORCID on file · 5 papers in corpus
2025
Factors influencing vaginal cuff dehiscence after laparoscopic hysterectomy and the psychological state of the patients.
World journal of psychiatry ·doi:10.5498/wjp.v15.i2.100062

BackgroundDespite laparoscopic total hysterectomy provided more benefits to patients and has become one of the most commonly used surgical methods for total hysterectomy. However, vaginal cuff dehiscence is a serious complication after lapa…

article 2015
C-Jun NH2-Terminal Kinase and p38 Inhibition Suppresses Prostaglandin E2-Stimulated Aromatase and Estrogen Receptor Levels in Human Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2015-2031

CONTEXT: Endometriosis is an estrogen-dependent disease. P38 and C-jun NH2-terminal kinase (JNK) inhibitors may have a therapeutic effect on endometriosis through regulation of prostaglandin E2 (PGE2)-induced estrogen metabolism. OBJECTIVE:…

article 2015
Metformin Suppresses Prostaglandin E2-Induced Cytochrome P450 Aromatase Gene Expression and Activity via Stimulation of AMP-Activated Protein Kinase in Human Endometriotic Stromal Cells
Reproductive sciences (Thousand Oaks, Calif.) ·doi:10.1177/1933719115590664

BackgroundCytochrome P450 aromatase (encoded by the CYP19A1/aromatase gene) plays a critical physiologic role in endometriosis. Metformin is known to suppress prostaglandin E2 (PGE2)-induced CYP19A1 messenger RNA (mRNA) expression in human …

article 2014
Metformin InhibitsStARExpression in Human Endometriotic Stromal Cells via AMPK-Mediated Disruption of CREB-CRTC2 Complex Formation
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-1593

CONTEXT: Endometriosis is an estrogen-dependent disease affecting reproductive women. Metformin could have a therapeutic effect on endometriosis through regulation of local estrogen production. OBJECTS: The aim of this study was to investig…

article 2014
Reproductive Performance after Surgery for Endometriosis: Predictive Value of the Revised American Fertility Society Classification and the Endometriosis Fertility Index
Gynecologic and obstetric investigation ·doi:10.1159/000358390

Background/Aims: To determine whether the revised American Fertility Society (rAFS) classification and endometriosis fertility index (EFI) predict pregnancy rates (PRs) in patients with surgically confirmed endometriosis attempting natural …