Jetten AM

ORCID: 0000-0003-0954-4445 · 1 paper in corpus

2020

Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Genes and immunity ·doi:10.1038/s41435-020-0096-6

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here its side chain is cleaved by CYP11A1 producing pregnenolone.…