Makoto Saegusa

ORCID: 0000-0001-5366-7149 · 7 papers in corpus · active 2015-2026

Study types

  • article 5
  • other 2

Condition tags

  • endometriosis 7
  • adenomyosis 1
other 2026
Two Giant Cystic Uterine Adenomyomas in a Premenopausal Woman: The Largest Case to Date With Immunohistochemical Findings
Case reports in obstetrics and gynecology ·doi:10.1155/crog/4595994

BACKGROUND AND AIMS: Cystic adenomyoma is a rare focal cystic variant of adenomyosis, and giant lesions are particularly uncommon. Malignant transformation has been reported in endometriosis-related disease, but the molecular features of cy…

article 2019
Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis–associated tumorigenesis
Human pathology ·doi:10.1016/j.humpath.2019.04.001
article 2019
Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions
BMC cancer ·doi:10.1186/s12885-019-5539-y

BACKGROUND: Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tum…

article 2016
Distinct β-Catenin and PIK3CA Mutation Profiles in

Objectives: We focused on the differences in molecular mechanisms in the early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and ovarian clear cell carcinoma (OCCCa). Methods: Alterations in the β-catenin and PIK…

article 2016
Ovarian endometrioid adenocarcinoma in a young woman with hemorrhagic shock due to tumor disintegration: A case report
·doi:10.1016/j.ehpc.2016.02.001

Acute abdomen secondary to ovarian carcinoma is rare, especially in a young woman. A 28-year-old obese woman underwent bilateral salpingo-oophorectomy and omentectomy as emergency surgery. The specimen from the right ovarian adenocarcinoma …

article 2015
Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas
American journal of clinical pathology ·doi:10.1309/ajcpz5t2poofmqvn

OBJECTIVES: We focused on the differences in molecular mechanisms in the early stages of endometriosis-associated ovarian endometrioid carcinoma (OEMCa) and ovarian clear cell carcinoma (OCCCa). METHODS: Alterations in the β-catenin and PIK…

other 2015
Transcriptional upregulation of HNF-1β by NF-κB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression
Laboratory investigation; a journal of technical methods and pathology ·doi:10.1038/labinvest.2015.73

Hepatocyte nuclear factor-1β (HNF-1β) is a transcriptional factor that has an important role in endometriosis-ovarian clear cell carcinoma (OCCC) sequence by modulating cell kinetics and glucose metabolism. However, little is known about th…