Zhen Lü

ORCID: 0000-0002-9596-0148 · 4 papers in corpus
2021
A MYC-Driven Plasma Polyamine Signature for Early Detection of Ovarian Cancer.
Cancers ·doi:10.3390/cancers13040913

MYC is an oncogenic driver in the pathogenesis of ovarian cancer. We previously demonstrated that MYC regulates polyamine metabolism in triple-negative breast cancer (TNBC) and that a plasma polyamine signature is associated with TNBC devel…

2017
The role of biomarkers in the management of epithelial ovarian cancer.
Expert review of molecular diagnostics ·doi:10.1080/14737159.2017.1326820

IntroductionDespite advances in surgery and chemotherapy for ovarian cancer, 70% of women still succumb to the disease. Biomarkers have contributed to the management of ovarian cancer by monitoring response to treatment, detecting recurrenc…

article 2015
MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology ·doi:10.1159/000374022

BACKGROUND/AIMS: Adenomyosis is a disease in which ectopic endometrial glands and stromal cells appear in the uterine myometrium. Despite its prevalence, the molecular mechanisms involved in the development of adenomyosis are largely unknow…

2009
CA125/MUC16 is dispensable for mouse development and reproduction.
PloS one ·doi:10.1371/journal.pone.0004675

Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian cancer (EOC) and is encoded by MUC16, a member of the mucin gene family. The biological function of CA125/MUC16 an…