Zhen Lü

ORCID: 0000-0002-9596-0148 · 4 papers in corpus
diagnostic-accuracy 2021
A MYC-Driven Plasma Polyamine Signature for Early Detection of Ovarian Cancer.
Cancers ·doi:10.3390/cancers13040913

MYC is an oncogenic driver in the pathogenesis of ovarian cancer. We previously demonstrated that MYC regulates polyamine metabolism in triple-negative breast cancer (TNBC) and that a plasma polyamine signature is associated with TNBC devel…

review 2017
The role of biomarkers in the management of epithelial ovarian cancer
Expert review of molecular diagnostics ·doi:10.1080/14737159.2017.1326820

Despite advances in surgery and chemotherapy for ovarian cancer, 70% of women still succumb to the disease. Biomarkers have contributed to the management of ovarian cancer by monitoring response to treatment, detecting recurrence, distingui…

lab-animal 2015
MiR-10b Directly Targets ZEB1 and PIK3CA to Curb Adenomyotic Epithelial Cell Invasiveness via Upregulation of E-Cadherin and Inhibition of Akt Phosphorylation
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology ·doi:10.1159/000374022

BACKGROUND/AIMS: Adenomyosis is a disease in which ectopic endometrial glands and stromal cells appear in the uterine myometrium. Despite its prevalence, the molecular mechanisms involved in the development of adenomyosis are largely unknow…

lab-animal 2009
CA125/MUC16 is dispensable for mouse development and reproduction
PloS one ·doi:10.1371/journal.pone.0004675

Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian cancer (EOC) and is encoded by MUC16, a member of the mucin gene family. The biological function of CA125/MUC16 an…