Sharpless NE

ORCID: 0000-0001-7078-9455 · 3 papers in corpus
2017
Senescence in Health and Disease.
Cell ·doi:10.1016/j.cell.2017.05.015

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variet…

2012
Review: a meta-analysis of GWAS and age-associated diseases.
Aging cell ·doi:10.1111/j.1474-9726.2012.00871.x

Genome-Wide Association studies (GWAS) offer an unbiased means to understand the genetic basis of traits by identifying single nucleotide polymorphisms (SNPs) linked to causal variants of complex phenotypes. GWAS have identified a host of s…

2010
Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.
PLoS genetics ·doi:10.1371/journal.pgen.1001233

Human genome-wide association studies have linked single nucleotide polymorphisms (SNPs) on chromosome 9p21.3 near the INK4/ARF (CDKN2a/b) locus with susceptibility to atherosclerotic vascular disease (ASVD). Although this locus encodes thr…