Otzen D

ORCID: 0000-0002-2918-8989 · 1 paper in corpus

2010

Flexibility of the thrombin-activatable fibrinolysis inhibitor pro-domain enables productive binding of protein substrates.

The Journal of biological chemistry ·doi:10.1074/jbc.m110.150342

We have previously reported that thrombin-activatable fibrinolysis inhibitor (TAFI) exhibits intrinsic proteolytic activity toward large peptides. The structural basis for this observation was clarified by the crystal structures of human an…